Concentration
Selective attention and task focus.
Ranked by evidence strength across reported benefits.
Creatine Monohydrate
The most-studied and effective ergogenic aid — replenishes ATP via the phosphocreatine system.
Omega-3 (EPA/DHA)
Marine long-chain omega-3s — the most-studied anti-inflammatory and cardiovascular nutrient.
Vitamin B12
Essential cobalamin for methylation, red blood cell formation, and myelin maintenance.
L-Theanine
Calm focus — alpha-wave amino acid from green tea that takes the edge off caffeine.
Caffeine
Adenosine antagonist with strong evidence for cognitive and physical performance.
Vitamin B1 (Thiamine)
Cofactor for carbohydrate metabolism and nerve conduction.
Methylfolate (L-5-MTHF)
Bioactive folate that bypasses the MTHFR enzyme — preferred in MTHFR variants and pregnancy.
Creatine Monohydrate
Gold-standard creatine form — the most studied supplement in sports science.
Mucuna Pruriens (Velvet Bean)
Natural L-DOPA source studied for Parkinson's, libido, and fertility.
Piracetam (Cognitive)
Original racetam used for cortical excitability disorders.
Methylcobalamin (B12)
Active methyl-form of B12 — directly usable in the methylation cycle.
Bacopa Monnieri
Ayurvedic nootropic with strong evidence for memory consolidation over 8–12 weeks.
Algal Omega-3 (Vegan EPA/DHA)
Plant-based EPA and DHA from microalgae for vegan diets.
Modafinil (Rx note)
Wakefulness-promoting Rx — listed for reference; not a supplement.
Choline Bitartrate
Affordable choline source — supports phospholipid synthesis and methylation.
Bacopa Monnieri
Ayurvedic nootropic with strong evidence for memory and recall after chronic dosing.
Omega-3 (rTG form)
Re-esterified triglyceride EPA/DHA — ~70% better absorption than ethyl ester form.
Algal Omega-3 (DHA/EPA)
Plant-source DHA (and some EPA) from cultivated marine algae — vegan alternative to fish oil.
Idebenone
Synthetic CoQ10 analog with better water solubility; used in LHON.
Guanfacine (Ref)
α2A-agonist reference drug for prefrontal focus and ADHD.
DHA (Prenatal)
Critical fatty acid for fetal brain and retinal development.
ALA (R-isomer)
Natural enantiomer of α-lipoic acid with better bioavailability.
L-Carnitine
Shuttles long-chain fatty acids into mitochondria for β-oxidation.
Rhodiola Rosea
Arctic adaptogen — reduces fatigue and improves mental performance under stress.
Curcumin
Yellow polyphenol from turmeric — anti-inflammatory and joint-supportive when properly bioavailable.
Choline
Essential nutrient for cell membranes, methylation, and acetylcholine synthesis.
Panax Ginseng
Adaptogenic ginseng studied for fatigue, cognition, and erectile function.
American Ginseng
Cooler adaptogen with stronger evidence for blood sugar and cold-flu prevention.
Mucuna Pruriens
Natural L-DOPA source studied for mood, libido, and Parkinson's.
Phosphatidylserine (PS)
Phospholipid that supports cognition and may blunt cortisol response to stress.
Salvia officinalis (Sage)
Culinary sage with cholinergic and anti-hyperhidrosis effects.
Alpha-GPC
Bioavailable choline source studied for cognition and acute power output.
Ginkgo Biloba
Vasoactive herb studied for cognition in the elderly and tinnitus.
Gotu Kola
Adaptogen used for cognitive support, anxiety, and wound healing.
Citicoline (CDP-Choline)
Phospholipid precursor with cytidine bonus — supports membranes and dopamine.
Ginkgo Biloba
Vasodilatory leaf extract for cognition and microcirculation.
Magnesium L-Threonate
Magnesium bound to L-threonic acid — the only form shown to meaningfully raise brain magnesium.
Krill Oil
Phospholipid-bound EPA/DHA from Antarctic krill — includes astaxanthin antioxidant.
Kanna (Sceletium)
South African succulent acting as SSRI + PDE4 inhibitor for mood and stress.
L-Tyrosine (Dopamine Replenishment)
Catecholamine precursor — replenishes dopamine/norepinephrine pools after stimulant use.
Vitamin B2 (Riboflavin)
FAD/FMN precursor central to redox reactions and migraine prophylaxis.
L-Tyrosine
Catecholamine precursor preserving cognition under stress and sleep deprivation.
Lemon Balm
Mild anxiolytic with cognitive calming effects via GABA-T inhibition.
Piracetam
Original racetam; modulates AMPA receptors and membrane fluidity. Rx in many countries.
Alpha-GPC (Cholinergic Recovery)
Choline source — supports acetylcholine after stimulant-driven depletion.
Huperzine A
Acetylcholinesterase inhibitor from club moss — potent cholinergic enhancer.
Uridine Monophosphate
Pyrimidine nucleoside — supports phosphatidylcholine synthesis and dopamine receptor density.
Riboflavin-5-Phosphate
Active form of B2 — used directly as FMN without liver conversion.
Benfotiamine
Lipid-soluble thiamine derivative with superior tissue penetration — used in diabetic neuropathy.
Sulbutiamine
Lipid-soluble thiamine derivative crossing the BBB for fatigue and focus.
Vinpocetine
Periwinkle alkaloid that increases cerebral blood flow.
Bifidobacterium longum 1714
Psychobiotic strain shown to reduce stress and improve memory.
Schisandra (Adaptogen)
Berry adaptogen for stress, focus, and liver protection.
Lemon Balm (Stress)
Melissa officinalis for acute stress and cognitive performance.
Spermidine (Wheat Germ)
Polyamine that induces autophagy and may extend lifespan.
Creatine (Cognitive Dose)
Higher-dose creatine for cognitive performance under stress.
Citicoline (Cognition)
Intermediate in phosphatidylcholine synthesis; boosts focus.
Uridine Monophosphate
Pyrimidine that supports synaptic membrane synthesis.
Phosphatidylcholine (PC)
Major brain and hepatic phospholipid often given for liver support.
5-HTP (Mood Dose)
Serotonin precursor used for mild depression and migraine.
Rosemary (Cognitive)
Rosmarinus officinalis for memory and mood via inhalation or oral.
Yerba Mate (Focus)
Polyphenolic stimulant alternative to coffee for focus.
Panax Ginseng (Cognitive)
Asian ginseng (G115) studied for mental performance.
Rhodiola SHR-5 (Fatigue)
Adaptogen for stress-related fatigue and burnout.
Butterbur
Petasites hybridus extract for migraine prophylaxis and allergic rhinitis.
Bacopa CDRI-08
Standardized Bacopa monnieri extract for memory.
Selank
Russian anxiolytic peptide based on tuftsin.
Semax
Russian nootropic ACTH analog for cognitive enhancement.
MCT C8 (Caprylic Acid)
Pure C8 medium-chain triglyceride for ketone production.
Mucuna Pruriens
Velvet bean providing natural L-DOPA.
Ergothioneine (Mushroom-Derived)
Natural ergothioneine from oyster mushrooms.
L-Phenylalanine
Precursor to tyrosine and catecholamines.
Theracurmin
Nano-particle curcumin for bioavailability.
Luteolin
Flavone with anti-inflammatory effects.
Lion's Mane Erinacines
Hericium erinaceus mycelium for NGF.
Lion's Mane Fruiting Body
Hericinones-rich beta-glucan source.
CDP-Choline (Citicoline)
Phospholipid precursor for cognition.
Soy Lecithin
Phosphatidylcholine source.
Phosphatidylcholine
Membrane phospholipid for liver.
Suntheanine
Pharmaceutical-grade L-theanine.
Picamilon
Niacin-GABA conjugate.
Aniracetam
Fat-soluble racetam.
Oxiracetam
Racetam for cognition.
Allithiamine
Garlic-derived fat-soluble thiamine.
Folinic Acid (Leucovorin)
Reduced folate form.
Methylcobalamin High-Dose
Active B12 form for neuropathy.
CDP-Choline (Citicoline)-Stroke
Acute stroke neuroprotection.
Noopept (GVS-111)
Russian dipeptide nootropic.
DMAE (Dimethylaminoethanol)
Choline analog for cognition.
Pyritinol
Pyridoxine derivative for cognition.
Galantamine (Plant-Derived)
Snowdrop alkaloid AChE inhibitor.
Ginkgo Biloba EGb 761
Standardized Ginkgo for cognition.
Biotin (High-Dose)
High-dose for MS and hair.
Enzogenol
New Zealand pine bark extract.
Pycnogenol (Pine Bark)
French maritime pine bark for circulation.
GOS (Galactooligosaccharides)
Galactose-based prebiotic.
6-Shogaol (Ginger)
Bioactive ginger compound.
Turmeric Essential Oil
Ar-turmerone for brain regeneration.
Longvida Curcumin
SLCP curcumin for brain bioavailability.
Lemon Balm Melissa Officinalis (Bluenesse)
Standardized Melissa for cognition.
DHA-Dominant Fish Oil
High-DHA for brain health.
Algae Omega-3
Vegan EPA/DHA source.
Salmon Roe Phospholipids
Phospholipid omega-3s from salmon eggs.
Lion's Mane
Edible medicinal mushroom that upregulates NGF and BDNF — studied for nerve growth and cognition.
Cistanche Tubulosa
Desert plant tonic for libido and cognition.
Lithium Orotate (low-dose)
Low-dose lithium salt studied for mood stability and neuroprotection.
Pregnenolone
Master steroid precursor; small doses studied for cognition and PTSD.
Noopept
Synthetic dipeptide (peptide-like) studied for cognition and neuroprotection; not FDA approved.
PQQ
Cofactor stimulating mitochondrial biogenesis (PGC-1α).
Magnesium L-Threonate
Mg form designed for brain penetration; studied for cognition and sleep.
Lion's Mane (Neuroregeneration)
NGF-upregulating mushroom — included in post-use stacks for neurotrophic support.
Pramiracetam
Racetam family — increases high-affinity choline uptake.
Agmatine Sulfate
Arginine metabolite with NMDA modulation and analgesic properties.
9-Me-BC
β-carboline alkaloid that upregulates dopamine neurons in animal models.
Centrophenoxine
Cholinergic precursor that reduces lipofuscin accumulation in neurons.
Phenylpiracetam Hydrazide
Hydrazide analog of phenylpiracetam reported to support memory and locomotion.
Coluracetam
Racetam acting on high-affinity choline uptake; studied for depression/anxiety.
Fisetin (Senolytic)
Polyphenol senolytic with neuroprotective and anti-inflammatory effects.
Ergothioneine (Extra)
Unique thiol antioxidant concentrated in mitochondria via OCTN1.
Noopept (High-Dose)
Russian dipeptide claimed to enhance BDNF and NGF.
Magnesium Acetyl-Taurate
Brain-penetrant Mg form combined with taurate for mood.