Men's Longevity
Male-specific aging concerns.
Ranked by evidence strength across reported benefits.
Melatonin
Pineal hormone that signals biological night — most effective for circadian-rhythm shifts.
Coffee
Caffeine + polyphenol matrix with strong evidence for mortality and T2D reduction.
N-Acetyl Cysteine (NAC)
Glutathione precursor with mucolytic, hepatoprotective, and psychiatric uses.
Vitamin B3 (Niacin)
NAD+ precursor; nicotinic acid form lowers LDL and raises HDL.
Vitamin C
Water-soluble antioxidant, collagen cofactor, and immune supporter.
Milk Thistle
Hepatoprotective herb with antioxidant and anti-fibrotic effects.
Garlic
Culinary bulb with cardiovascular benefits primarily via allicin and aged-garlic compounds.
Glycine
Inhibitory amino acid that improves sleep quality, glycemic control, and collagen synthesis.
Nicotinamide Riboside (NR)
NAD+ precursor with bioavailability and longevity research interest.
NMN
NAD+ precursor similar to NR; bioavailability route debated.
Nicotinamide Riboside (NR)
NAD+ precursor that bypasses the flush — studied for cellular aging.
Alpha-Lipoic Acid
Mitochondrial antioxidant studied for diabetic neuropathy and insulin sensitivity.
Idebenone
Synthetic CoQ10 analog with better water solubility; used in LHON.
Selenium-Enriched Yeast
Yeast-bound selenomethionine — form used in major chemoprevention trials.
ALA (R-isomer)
Natural enantiomer of α-lipoic acid with better bioavailability.
Tongkat Ali
Malaysian root extract that frees bound testosterone via SHBG reduction.
Zinc
Cofactor for ~300 enzymes — critical for testosterone, immune function, and DNA synthesis.
Vitamin K2 (MK-7)
Activates the proteins that direct calcium into bone — not arteries.
Coenzyme Q10
Mitochondrial electron carrier and lipid-soluble antioxidant.
Glycine
Inhibitory neurotransmitter that improves sleep quality and supports collagen synthesis.
Vitamin E
Primary lipid-phase antioxidant protecting membrane PUFAs.
Pomegranate
Polyphenol-rich fruit converted by gut microbes to urolithin A (mitochondrial benefit).
Green Tea (EGCG)
Polyphenol-rich tea; EGCG modestly boosts metabolism and supports cardiovascular health.
DHEA
Adrenal androgen precursor declining with age; used for adrenal insufficiency and aging.
Astaxanthin
Algal carotenoid that is the strongest membrane antioxidant; UV and eye protection.
Tongkat Ali (Eurycoma longifolia)
Malaysian root with moderate human evidence for raising free testosterone and reducing SHBG.
Alpha-Lipoic Acid (ALA)
Universal antioxidant that's both water and fat soluble — supports glycemic control and nerve health.
Yohimbine
Alpha-2 antagonist — improves erection and fat loss in fasted state but cardiovascular caution.
Ubiquinol (CoQ10)
Reduced active form of CoQ10 — preferred in adults over 40 and those with statin-induced depletion.
Vitamin K2 (MK-7)
Long-half-life K2 — directs calcium to bone and away from arteries.
Astaxanthin (Eye dose)
Carotenoid that crosses BBB and accumulates in ciliary body.
Taurine
Conditionally essential amino acid involved in bile salt conjugation, osmoregulation, and cardiac function.
Glutathione
Master intracellular antioxidant; oral bioavailability depends on form.
TUDCA
Bile acid with hepatoprotective effects and ER stress reduction.
Ginkgo Biloba
Vasoactive herb studied for cognition in the elderly and tinnitus.
Shilajit
Himalayan mineral exudate rich in fulvic acid, studied for testosterone and fatigue.
Reishi
Adaptogenic mushroom used for immune balance, sleep, and stress.
DIM (Diindolylmethane)
Cruciferous-derived compound modulating estrogen metabolism toward 2-OH pathway.
Quercetin
Flavonoid with antihistamine and senolytic effects; pairs with bromelain or vitamin C.
Saw Palmetto
5α-reductase-inhibiting berry extract — used for BPH and androgenic hair loss.
TUDCA (Tauroursodeoxycholic Acid)
Conjugated bile acid — hepatoprotective and ER-stress-reducing.
Resveratrol
Polyphenol from grapes — sirtuin activator with mixed human evidence.
Taurine
Conditionally essential amino acid with cardiovascular, metabolic, and longevity effects.
DIM (Diindolylmethane)
Cruciferous-vegetable metabolite that shifts estrogen metabolism toward 2-OH (protective) pathways.
Magnesium L-Threonate
Magnesium bound to L-threonic acid — the only form shown to meaningfully raise brain magnesium.
NMN (Nicotinamide Mononucleotide)
Direct NAD+ precursor — popular longevity supplement with growing human data.
Taurine (High-Dose)
Conditionally essential amino acid with longevity and metabolic effects.
Selenium
Trace mineral essential for glutathione peroxidase and thyroid hormone activation.
Saw Palmetto
Lipidosterolic extract used for BPH urinary symptoms.
Pygeum
African plum bark used for BPH urinary symptoms.
Stinging Nettle Root
Herbal for BPH and SHBG modulation, often paired with saw palmetto.
Krill Oil
Phospholipid-bound omega-3 with astaxanthin; better bioavailability than fish oil per gram.
Resveratrol
Polyphenol activating sirtuins; bioavailability and clinical effects modest.
Urolithin A
Gut-microbial metabolite of ellagitannins — induces mitophagy.
Panax Ginseng (Sexual Health)
Korean red ginseng with RCT-level evidence for erectile dysfunction.
Zinc (Sperm Health)
Concentrated in semen — essential for sperm production and testosterone.
Curcumin Phytosome (Meriva)
Phosphatidylcholine-complexed curcumin — ~29× higher bioavailability than standard extract.
Selenomethionine
Organic selenium form — preferred for thyroid (Hashimoto's) and antioxidant support.
Lycopene
Tomato carotenoid linked with prostate and cardiovascular protection.
Pterostilbene (Extra)
Methylated resveratrol analog with superior bioavailability.
Tocotrienols (Skin/Aging)
Vitamin E isoforms with 40–60× higher antioxidant power than tocopherols.
Trans-Resveratrol (Pure)
Purified active isomer of resveratrol.
Spermidine (Wheat Germ)
Polyamine that induces autophagy and may extend lifespan.
Urolithin A (Mitopure)
Gut-derived ellagitannin metabolite that induces mitophagy.
Boron (Extra)
Trace mineral that modulates steroid hormones and bone.
Mixed Tocopherols
Full-spectrum natural vitamin E avoiding α-only supplementation pitfalls.
Epitalon
Tetrapeptide that activates telomerase.
MOTS-c
Mitochondrial-derived peptide for metabolic regulation.
SS-31 (Elamipretide)
Mitochondrial-targeted peptide for cardiolipin protection.
Glycine + NAC (GlyNAC)
Glutathione-boosting combination for aging.
Rapamycin
mTOR inhibitor studied for longevity (Rx only).
Metformin (Longevity Use)
Biguanide diabetes drug studied for healthspan.
Mucuna Pruriens
Velvet bean providing natural L-DOPA.
MitoQ
Mitochondria-targeted ubiquinone (CoQ10 analog).
PQQ (Pyrroloquinoline Quinone)
Redox cofactor for mitochondrial biogenesis.
C60 in Olive Oil
Buckminsterfullerene antioxidant.
Ergothioneine (Mushroom-Derived)
Natural ergothioneine from oyster mushrooms.
Hydroxytyrosol
Olive polyphenol for cardiovascular health.
Selenium (Selenomethionine)
Antioxidant trace element for thyroid.
Nettle Root
Urtica dioica for BPH.
Beta-Sitosterol
Plant sterol for BPH and cholesterol.
Black Maca
Lepidium meyenii black variant for energy.
Red Maca
Lepidium meyenii red variant for prostate.
Trans-Resveratrol
Active form of resveratrol.
Micronized Resveratrol
Improved bioavailability resveratrol.
Pomegranate Extract
Punica granatum ellagitannins.
Punicalagin
Major pomegranate ellagitannin.
Ellagic Acid
Ellagitannin hydrolysis product.
Tongkat Ali Eurycomanone-Standardized
LJ100 standardized to 22% eurypeptides.
Stinging Nettle Root
Urtica dioica root for free testosterone.
Boron Citrate
Boron for hormone modulation.
Zinc Monomethionine (ZMA)
Zinc + magnesium + B6 for recovery.
Honokiol
Active magnolia compound.
Oleocanthal
EVOO ibuprofen-like compound.
Lion's Mane
Edible medicinal mushroom that upregulates NGF and BDNF — studied for nerve growth and cognition.
Fisetin
Flavonoid studied as senolytic — clearing senescent cells in animal models.
Pumpkin Seed Oil
Cold-pressed seed oil studied for hair density and prostate health.
Boron
Trace mineral with modest effects on free testosterone and bone mineralization.
Quercetin
Flavonoid with antihistamine, anti-viral, and senolytic activity.
Tocotrienols (Vitamin E)
Unsaturated vitamin E family — superior antioxidant capacity vs alpha-tocopherol.
Fadogia Agrestis
Nigerian shrub — popularized for testosterone support; sparse human data.
Lithium Orotate (low-dose)
Low-dose lithium salt studied for mood stability and neuroprotection.
Chaga
Birch-tree mushroom rich in melanin, betulin, and antioxidants.
PQQ
Cofactor stimulating mitochondrial biogenesis (PGC-1α).
Pterostilbene
Bioavailable resveratrol analog with longer half-life.
Spermidine
Polyamine inducing autophagy; epidemiologic association with longevity.
ALCAR + ALA (Mitochondrial Protection)
Mitochondrial antioxidant stack — popularized as harm-reduction adjunct for MDMA neuroprotection.
EGCG (Green Tea Catechin)
Potent CYP/COMT-modulating antioxidant — popularized in MDMA harm-reduction stacks.
Pterostilbene
Methylated analog of resveratrol — better bioavailability and longer half-life.
Spermidine
Polyamine that induces autophagy — emerging longevity supplement.
Horny Goat Weed (Epimedium)
Icariin-rich herb with PDE5-inhibitor-like activity for erectile function.
Zinc Picolinate
Zinc chelated to picolinic acid — one of the most bioavailable oral forms.
Liposomal Glutathione
Phospholipid-encapsulated GSH — protects from gut breakdown for systemic delivery.
S-Acetyl Glutathione
Acetylated GSH — stable through the gut and converted intracellularly to glutathione.
9-Me-BC
β-carboline alkaloid that upregulates dopamine neurons in animal models.
Centrophenoxine
Cholinergic precursor that reduces lipofuscin accumulation in neurons.
Pine Pollen
Phyto-androgen pollen containing trace testosterone and DHEA.
Thymulin (Reference)
Zinc-dependent thymic peptide that matures T-cells.
Alpha-Ketoglutarate (AKG)
TCA-cycle intermediate studied for healthspan and frailty.
Fisetin (Senolytic)
Polyphenol senolytic with neuroprotective and anti-inflammatory effects.
Quercetin + Dasatinib (D+Q)
Reference senolytic combination cycled to clear senescent cells.
L-Carnosine
Dipeptide that buffers protons and reduces advanced glycation end-products.
Ergothioneine (Extra)
Unique thiol antioxidant concentrated in mitochondria via OCTN1.
Topical Saw Palmetto
Topical lotion form for androgenetic alopecia.
Fadogia Agrestis
African shrub touted for testosterone (rodent data only).
Fadogia Agrestis
African shrub popularized for testosterone; limited human data and toxicology concerns.