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Autoimmune Support

Th17/Treg balance modulators.

Ranked by evidence strength across reported benefits.

Vitamin#1· strong

Vitamin D3

Steroid hormone precursor regulating ~5% of the human genome — bone, immune, and hormonal health.

Fatty Acid#2· strong

Omega-3 (EPA/DHA)

Marine long-chain omega-3s — the most-studied anti-inflammatory and cardiovascular nutrient.

Amino Acid#3· strong

N-Acetyl Cysteine (NAC)

Glutathione precursor with mucolytic, hepatoprotective, and psychiatric uses.

Herb#4· strong

Ginger

Culinary rhizome with strong antiemetic and anti-inflammatory effects.

Vitamin#5· strong

Vitamin A (Retinol)

Fat-soluble vitamin essential for vision, immune function, and epithelial integrity.

Vitamin#6· strong

Vitamin C

Water-soluble antioxidant, collagen cofactor, and immune supporter.

Herb#7· strong

Garlic

Culinary bulb with cardiovascular benefits primarily via allicin and aged-garlic compounds.

Herb#8· strong

Boswellia

Anti-inflammatory resin used for osteoarthritis and IBD.

Compound#9· strong

Lactobacillus Probiotics

Lactic acid bacteria supporting gut barrier, immunity, and women's urogenital health.

Compound#10· strong

Beta-Glucan

Polysaccharide that primes innate immune cells (yeast) or lowers cholesterol (oat).

Compound#11· strong

CBD (Cannabidiol)

Non-intoxicating cannabinoid studied for anxiety, sleep, and seizures.

Vitamin#12· strong

Vitamin D3 (Cholecalciferol)

Preferred form for raising 25(OH)D — the active form your skin makes from sun.

Herb#13· strong

Aged Garlic Extract (Kyolic)

Odorless aged garlic with S-allyl-cysteine for vascular health.

Compound#14· strong

Capsaicin

Chili pepper compound that mildly increases thermogenesis and reduces appetite.

Mushroom#15· strong

Turkey Tail

Beta-glucan-rich mushroom used as immune adjunct in cancer (PSK approved in Japan).

Compound#16· strong

Saccharomyces Boulardii

Beneficial yeast used to prevent and treat several types of diarrhea.

Herb#17· strong

Andrographis

Bitter herb with strong RCT evidence for URI symptom reduction.

Mineral#18· strong

Zinc Gluconate

Most common over-the-counter zinc form — affordable, moderate bioavailability.

Fatty Acid#19· strong

Omega-3 (rTG form)

Re-esterified triglyceride EPA/DHA — ~70% better absorption than ethyl ester form.

Herb#20· strong

Andrographis (KalmCold)

Standardized andrographolide for acute upper respiratory infections.

Herb#21· strong

Pelargonium sidoides (Umckaloabo)

South African geranium root for acute bronchitis and URIs.

Vitamin#22· strong

Vitamin D3 (Maintenance)

Daily maintenance dose for non-deficient adults.

Vitamin#23· strong

Vitamin D3 (Repletion)

Repletion dose for deficiency under medical supervision.

Mineral#24· strong

Selenium-Enriched Yeast

Yeast-bound selenomethionine — form used in major chemoprevention trials.

Mineral#25· moderate

Zinc

Cofactor for ~300 enzymes — critical for testosterone, immune function, and DNA synthesis.

Herb#26· moderate

Curcumin

Yellow polyphenol from turmeric — anti-inflammatory and joint-supportive when properly bioavailable.

Amino Acid#27· moderate

L-Glutamine

Most abundant amino acid; primary fuel for enterocytes and immune cells.

Herb#28· moderate

American Ginseng

Cooler adaptogen with stronger evidence for blood sugar and cold-flu prevention.

Herb#29· moderate

Licorice Root

Adrenal-supporting herb; chronic high-dose causes pseudo-aldosteronism.

Compound#30· moderate

Bromelain

Pineapple proteolytic enzyme with anti-inflammatory and fibrinolytic effects.

Compound#31· moderate

Bovine Colostrum

First milk rich in IgG, lactoferrin, and growth factors for immune and gut support.

Compound#32· moderate

Lactoferrin

Iron-binding protein with antimicrobial and immunomodulating effects.

Mushroom#33· moderate

Reishi

Adaptogenic mushroom used for immune balance, sleep, and stress.

Compound#34· moderate

Quercetin

Flavonoid with antihistamine and senolytic effects; pairs with bromelain or vitamin C.

Compound#35· moderate

MSM (Methylsulfonylmethane)

Bioavailable sulfur donor for joints, skin, and hair-keratin synthesis.

Mineral#36· moderate

Selenium

Trace mineral essential for glutathione peroxidase and thyroid hormone activation.

Mushroom#37· moderate

Cordyceps

Medicinal fungus studied for aerobic capacity and immune modulation.

Mushroom#38· moderate

Shiitake (Lentinan)

Culinary mushroom whose beta-glucan lentinan is an approved injectable immune adjunct.

Herb#39· moderate

Olive Leaf Extract

Mediterranean herb with antihypertensive and immune effects.

Compound#40· moderate

Bifidobacterium Probiotics

Dominant probiotic genus in the colon; supports immune and gut barrier.

Herb#41· moderate

Elderberry

Anthocyanin-rich berry used to shorten influenza and URI symptoms.

Herb#42· moderate

Echinacea

Native American herb used for URI prevention/duration reduction.

Herb#43· moderate

Cranberry

Berry with PACs that inhibit E. coli adhesion to urothelium for UTI prevention.

Herb#44· moderate

Aged Garlic Extract (Kyolic)

Standardized aged garlic — modest BP and cholesterol benefits.

Herb#45· moderate

Boswellia Serrata

Frankincense extract with 5-LOX inhibition — robust evidence for OA pain.

Mineral#46· moderate

Zinc Acetate

Lozenge form shown to shorten cold duration when used at first symptoms.

Herb#47· moderate

Curcumin Phytosome (Meriva)

Phosphatidylcholine-complexed curcumin — ~29× higher bioavailability than standard extract.

Herb#48· moderate

Curcumin C3 + Piperine

Classic curcumin extract with black pepper extract — boosts bioavailability ~20× via UGT inhibition.

Mushroom#49· moderate

Agaricus blazei

Brazilian mushroom rich in β-glucans for immune modulation.

Mushroom#50· moderate

Maitake D-Fraction

Standardized β-glucan from Grifola frondosa for immune support.

Compound#51· moderate

Spirulina (Extra Profile)

Cyanobacterium with phycocyanin for allergy and immunity.

Mineral#52· moderate

Zinc Bisglycinate (High-Bio)

Chelated zinc with superior absorption and tolerability.

Herb#53· moderate

Butterbur

Petasites hybridus extract for migraine prophylaxis and allergic rhinitis.

Herb#54· moderate

Cat's Claw

Uncaria tomentosa for joint pain and immunity.

Mushroom#55· moderate

Agaricus Blazei

Brazilian sun mushroom for immune support.

Mushroom#56· moderate

Phellinus Linteus

Meshima mushroom with hispolon for immune support.

Compound#57· moderate

PEA (Palmitoylethanolamide)

Endogenous fatty acid amide for pain and inflammation.

Amino Acid#58· moderate

L-Lysine

Essential amino acid for collagen and HSV prevention.

Mineral#59· moderate

Selenium (Selenomethionine)

Antioxidant trace element for thyroid.

Compound#60· moderate

Quercetin Phytosome

Lecithin-complexed quercetin.

Compound#61· moderate

Quercetin + Bromelain

Anti-inflammatory pair for allergies.

Herb#62· moderate

Stinging Nettle Leaf

Urtica dioica leaf for allergies and joint pain.

Compound#63· moderate

Isoquercetin

Highly bioavailable quercetin glycoside.

Compound#64· moderate

Luteolin

Flavone with anti-inflammatory effects.

Compound#65· moderate

Baicalin

Scutellaria baicalensis flavonoid.

Herb#66· moderate

Pelargonium Sidoides

South African geranium for bronchitis.

Herb#67· moderate

EPs 7630

Standardized Pelargonium extract.

Herb#68· moderate

Echinacea Purpurea

Coneflower for upper respiratory infections.

Herb#69· moderate

Echinacea Angustifolia

Narrow-leaf coneflower for immune support.

Mushroom#70· moderate

Lion's Mane Fruiting Body

Hericinones-rich beta-glucan source.

Mushroom#71· moderate

Agarikon (Fomitopsis officinalis)

Antiviral polypore mushroom.

Mushroom#72· moderate

Poria Cocos

TCM mushroom for sleep and immunity.

Mushroom#73· moderate

Oyster Mushroom

Pleurotus ostreatus with ergothioneine.

Herb#74· moderate

Butterbur Ze 339

PA-free butterbur for allergic rhinitis.

Herb#75· moderate

Marshmallow Root

Althaea officinalis mucilage for cough.

Herb#76· moderate

Cranberry Extract

Vaccinium macrocarpon for UTI prevention.

Herb#77· moderate

Olive Leaf (Standardized Oleuropein)

High-oleuropein extract.

Fatty Acid#78· moderate

Lauric Acid

Coconut MCFA with antimicrobial activity.

Fatty Acid#79· moderate

Black Seed Oil (Nigella sativa)

Thymoquinone for immune and metabolic health.

Compound#80· moderate

Thymoquinone

Active black seed compound.

Compound#81· moderate

Propolis

Bee glue with caffeic acid phenethyl ester.

Compound#82· moderate

Bee Pollen

Pollen collected by bees.

Compound#83· moderate

Manuka Honey

Leptospermum honey with MGO.

Compound#84· moderate

Bromelain

Pineapple proteolytic enzyme.

Herb#85· moderate

Ginger Extract (Zingiber)

Standardized ginger for nausea and inflammation.

Herb#86· moderate

Galangal (Alpinia)

Thai ginger relative for inflammation.

Herb#87· moderate

Holy Basil (Tulsi)

Ocimum sanctum adaptogen.

Compound#88· moderate

Holy Basil Eugenol

Active constituent of tulsi.

Vitamin#89· moderate

Liposomal Vitamin C

Phospholipid-encapsulated vitamin C.

Vitamin#90· moderate

Ascorbyl Palmitate

Fat-soluble vitamin C ester.

Vitamin#91· moderate

Sodium Ascorbate

Buffered vitamin C form.

Compound#92· moderate

Bovine Colostrum

First milk with growth factors.

Compound#93· moderate

Chlorella

Green algae with chlorophyll.

Herb#94· moderate

Amla (Indian Gooseberry)

Phyllanthus emblica vitamin C source.

Fatty Acid#95· moderate

Black Cumin Seed Oil

Nigella sativa oil.

Herb#96· limited

Eleuthero

Adaptogen used to support stamina, immune function, and stress resilience.

Fatty Acid#97· limited

Evening Primrose Oil

Omega-6 source rich in GLA, used for atopic dermatitis and cyclical breast pain.

Compound#98· limited

Quercetin

Flavonoid with antihistamine, anti-viral, and senolytic activity.

Mushroom#99· limited

Chaga

Birch-tree mushroom rich in melanin, betulin, and antioxidants.

Compound#100· limited

Serrapeptase

Silkworm-derived proteolytic enzyme used for inflammation and fibrin breakdown.

Compound#101· limited

Monolaurin

Coconut-derived monoglyceride with antimicrobial properties against enveloped viruses.

Vitamin#102· limited

Vitamin C (Harm-Reduction Antioxidant)

Water-soluble antioxidant — quenches dopamine quinone and other reactive metabolites.

Mineral#103· limited

Zinc Picolinate

Zinc chelated to picolinic acid — one of the most bioavailable oral forms.

Mineral#104· limited

Zinc Bisglycinate

Glycine-chelated zinc — high absorption and very gentle on the stomach.

Compound#105· limited

Liposomal Glutathione

Phospholipid-encapsulated GSH — protects from gut breakdown for systemic delivery.

Herb#106· limited

Chinese Skullcap

Flavonoid-rich root used for anxiety and inflammation.

Peptide#107· limited

Thymulin (Reference)

Zinc-dependent thymic peptide that matures T-cells.

Mineral#108· limited

Calcium AEP (Membrane Calcium)

Cell-membrane-targeted form of calcium claimed for autoimmune support.