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evidence · mechanism · dose
Supplements/Herb

Curcumin C3 + Piperine

Classic curcumin extract with black pepper extract — boosts bioavailability ~20× via UGT inhibition.

Chronic InflammationJoint & Connective Tissue

Overview

Classic curcumin extract with black pepper extract — boosts bioavailability ~20× via UGT inhibition.

Natural sources
    Common forms

      Forms & variants of Curcumin

      Different chemical forms of Curcumin behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Curcumin

      Yellow polyphenol from turmeric — anti-inflammatory and joint-supportive when properly bioavailable.

      Meriva (Phytosome)
      Curcumin Phytosome (Meriva)

      Phosphatidylcholine-complexed curcumin — ~29× higher bioavailability than standard extract.

      Mechanism of action

      Piperine inhibits glucuronidation, slowing curcumin clearance.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves inflammatory markers in OA and RA

        Moderate evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              Drugs metabolized by CYP3A4
              Piperine inhibits CYP3A4 — check meds.
              moderate

              Safety & non-supplemental interactions

              Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

              Avoid if you are
              • ·Pregnant or breastfeeding (insufficient safety data)
              • ·Children under 18 (unless directed by a clinician)

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              500–1000 mg curcumin + 5–10 mg piperine
              With food?
              With fat

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Herb
              Curcumin C3 …
              Amazon
              Wide selection · fast shipping
              Herb
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              iHerb
              Global delivery · curated brands
              Herb
              Curcumin C3 …
              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              RCTPlanta Med · 1998

              Curcumin C3 + piperine and absorption

              Shoba G, et al.

              Pharmacokinetic crossover of curcumin ± piperine.

              Key findings

              Piperine increased curcumin bioavailability 2000%.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Curcumin C3 + Piperine — Improves inflammatory markers in OA and RA

              Live PubMed search

              Live results for "Curcumin C3 + Piperine Improves inflammatory markers in OA and RA" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Curcumin C3 + Piperine and "Improves inflammatory markers in OA and RA". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Curcumin C3 + Piperine — randomized controlled trial

              Live PubMed search

              Live results for "Curcumin C3 + Piperine randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Curcumin C3 + Piperine and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Curcumin C3 + Piperine — meta-analysis

              Live PubMed search

              Live results for "Curcumin C3 + Piperine meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Curcumin C3 + Piperine and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Curcumin C3 + Piperine — pharmacokinetics

              Live PubMed search

              Live results for "Curcumin C3 + Piperine pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Curcumin C3 + Piperine and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Curcumin C3 + Piperine — safety adverse events

              Live PubMed search

              Live results for "Curcumin C3 + Piperine safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Curcumin C3 + Piperine and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Curcumin C3 + Piperine — dose response

              Live PubMed search

              Live results for "Curcumin C3 + Piperine dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Curcumin C3 + Piperine and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: Curcumin C3 + Piperine — clinical evidence

              Live Scholar search

              Cross-database citation index for Curcumin C3 + Piperine as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.