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evidence · mechanism · dose
Supplements/Compound

Serrapeptase

Silkworm-derived proteolytic enzyme used for inflammation and fibrin breakdown.

Chronic InflammationJoint & Connective Tissue

Overview

Silkworm-derived proteolytic enzyme used for inflammation and fibrin breakdown.

Natural sources
  • Serratia bacteria
Common forms
  • Enteric-coated serrapeptase

Forms & variants of Serrapeptase

Different chemical forms of Serrapeptase behave differently. Browse each form's mechanism, bioavailability, and best-use context.

High-dose enteric
Serrapeptase (Extra)

Enteric-coated proteolytic enzyme for inflammation and mucus.

Mechanism of action

Hydrolyzes fibrin and dead tissue.

Pathways
  • · Fibrinolysis

Effects on the body

Decreases
Inflammation/edema

Organ system effects

Joints

Possible reduction in arthritis pain.

Evidence-based benefits

Limited but suggestive evidence for inflammatory conditions

Limited evidence

Potential side effects

Common
  • · GI upset
Rare
    Serious
    • · Pneumonitis case reports

    Drug interactions

    Anticoagulants
    Fibrinolytic.
    moderate

    Supplement interactions

    Pairs well with

    None listed.

    Avoid combining with

    No specific avoidances listed.

    Dosing & bioavailability

    Typical dose
    10–60 mg enteric, empty stomach

    Where to buy

    Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

    Compound
    Serrapeptase
    Amazon
    Wide selection · fast shipping
    Compound
    Serrapeptase
    iHerb
    Global delivery · curated brands
    Compound
    Serrapeptase
    Thorne
    Practitioner-grade · NSF tested

    Scientific evidence (8)

    Systematic reviewInt J Surg · 2013

    Serratiopeptidase in inflammation and pain

    Bhagat S, et al.

    Review of serratiopeptidase clinical evidence.

    Key findings

    Anti-inflammatory effects in postoperative swelling and ENT conditions.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Serrapeptase — Limited but suggestive evidence for inflammatory conditions

    Live PubMed search

    Live results for "Serrapeptase Limited but suggestive evidence for inflammatory conditions" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Serrapeptase and "Limited but suggestive evidence for inflammatory conditions". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Serrapeptase — randomized controlled trial

    Live PubMed search

    Live results for "Serrapeptase randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Serrapeptase and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Serrapeptase — meta-analysis

    Live PubMed search

    Live results for "Serrapeptase meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Serrapeptase and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Serrapeptase — pharmacokinetics

    Live PubMed search

    Live results for "Serrapeptase pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Serrapeptase and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Serrapeptase — safety adverse events

    Live PubMed search

    Live results for "Serrapeptase safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Serrapeptase and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Serrapeptase — dose response

    Live PubMed search

    Live results for "Serrapeptase dose response" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Serrapeptase and "dose response". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewGoogle Scholar · 1970

    Google Scholar: Serrapeptase — clinical evidence

    Live Scholar search

    Cross-database citation index for Serrapeptase as it relates to "clinical evidence".

    Key findings

    Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

    Open study
    Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.