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Supplements/Compound

Serrapeptase (Extra)

Enteric-coated proteolytic enzyme for inflammation and mucus.

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Overview

Enteric-coated proteolytic enzyme for inflammation and mucus.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Forms & variants of Serrapeptase

Different chemical forms of Serrapeptase behave differently. Browse each form's mechanism, bioavailability, and best-use context.

Mechanism of action

Hydrolyzes bradykinin, fibrin, and inflammatory mediators.

Pathways
  • · Hydrolyzes bradykinin, fibrin
  • · and inflammatory mediators

Effects on the body

Decreases
post-surgical swelling

Organ system effects

Evidence-based benefits

Reduces post-surgical swelling

Moderate evidence

Potential side effects

Common
  • · GI upset
Rare
  • · Pneumonitis
Serious

    Drug interactions

    Prescription medications (general)
    Always disclose Serrapeptase (Extra) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
    minor

    Supplement interactions

    Pairs well with
    • A high-quality multivitamin
      Covers micronutrient cofactors that support most supplement pathways.
    • Omega-3 (EPA/DHA)
      Foundational anti-inflammatory support that complements most regimens.
    Avoid combining with

    No specific avoidances listed.

    Dosing & bioavailability

    Typical dose
    10–60 mg enteric-coated
    Best form
    Most evidence is based on the capsule or softgel form.
    Timing
    Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
    With food?
    Empty stomach

    Where to buy

    Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

    Scientific evidence8Show studies
    RCTJ Int Med Res · 1984

    Serrapeptase post dental surgery

    Tachibana M, et al.

    RCT in 174 patients after molar extraction.

    Key findings

    Significantly reduced swelling and trismus vs placebo.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Serrapeptase (Extra) — Reduces post-surgical swelling

    Live PubMed search

    Live results for "Serrapeptase (Extra) Reduces post-surgical swelling" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Serrapeptase (Extra) and "Reduces post-surgical swelling". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Serrapeptase (Extra) — randomized controlled trial

    Live PubMed search

    Live results for "Serrapeptase (Extra) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Serrapeptase (Extra) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Serrapeptase (Extra) — meta-analysis

    Live PubMed search

    Live results for "Serrapeptase (Extra) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Serrapeptase (Extra) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Serrapeptase (Extra) — pharmacokinetics

    Live PubMed search

    Live results for "Serrapeptase (Extra) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Serrapeptase (Extra) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Serrapeptase (Extra) — safety adverse events

    Live PubMed search

    Live results for "Serrapeptase (Extra) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Serrapeptase (Extra) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Serrapeptase (Extra) — dose response

    Live PubMed search

    Live results for "Serrapeptase (Extra) dose response" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Serrapeptase (Extra) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewGoogle Scholar · 1970

    Google Scholar: Serrapeptase (Extra) — clinical evidence

    Live Scholar search

    Cross-database citation index for Serrapeptase (Extra) as it relates to "clinical evidence".

    Key findings

    Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

    Open study
    Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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