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evidence · mechanism · dose
Supplements/Compound

Serrapeptase (Extra)

Enteric-coated proteolytic enzyme for inflammation and mucus.

Overview

Enteric-coated proteolytic enzyme for inflammation and mucus.

Natural sources
    Common forms

      Forms & variants of Serrapeptase

      Different chemical forms of Serrapeptase behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Serrapeptase

      Silkworm-derived proteolytic enzyme used for inflammation and fibrin breakdown.

      Mechanism of action

      Hydrolyzes bradykinin, fibrin, and inflammatory mediators.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces post-surgical swelling

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
        • · Pneumonitis
        Serious

          Drug interactions

          No notable interactions reported.

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          10–60 mg enteric-coated
          With food?
          Empty stomach

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

          Compound
          Serrapeptase…
          Amazon
          Wide selection · fast shipping
          Compound
          Serrapeptase…
          iHerb
          Global delivery · curated brands
          Compound
          Serrapeptase…
          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (8)

          RCTJ Int Med Res · 1984

          Serrapeptase post dental surgery

          Tachibana M, et al.

          RCT in 174 patients after molar extraction.

          Key findings

          Significantly reduced swelling and trismus vs placebo.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Serrapeptase (Extra) — Reduces post-surgical swelling

          Live PubMed search

          Live results for "Serrapeptase (Extra) Reduces post-surgical swelling" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Serrapeptase (Extra) and "Reduces post-surgical swelling". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Serrapeptase (Extra) — randomized controlled trial

          Live PubMed search

          Live results for "Serrapeptase (Extra) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Serrapeptase (Extra) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Serrapeptase (Extra) — meta-analysis

          Live PubMed search

          Live results for "Serrapeptase (Extra) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Serrapeptase (Extra) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Serrapeptase (Extra) — pharmacokinetics

          Live PubMed search

          Live results for "Serrapeptase (Extra) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Serrapeptase (Extra) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Serrapeptase (Extra) — safety adverse events

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          Live results for "Serrapeptase (Extra) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

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          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Serrapeptase (Extra) — dose response

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          Live results for "Serrapeptase (Extra) dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Serrapeptase (Extra) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Serrapeptase (Extra) — clinical evidence

          Live Scholar search

          Cross-database citation index for Serrapeptase (Extra) as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.