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Weight Management

Fat loss, appetite, metabolism, and glucose control.

Ranked by evidence strength across reported benefits.

Compound#1· strong

Creatine Monohydrate

The most-studied and effective ergogenic aid — replenishes ATP via the phosphocreatine system.

Mineral#2· strong

Magnesium

Essential cofactor in 300+ enzymatic reactions, from ATP production to muscle relaxation.

Herb#3· strong

Ashwagandha

Adaptogenic herb that down-regulates HPA-axis output — lowers cortisol, supports T in stressed men.

Compound#4· strong

Coffee

Caffeine + polyphenol matrix with strong evidence for mortality and T2D reduction.

Compound#5· strong

Whey Protein

Fast-digesting complete protein rich in leucine for muscle protein synthesis.

Compound#6· strong

Psyllium Husk

Soluble fiber with strong evidence for cholesterol reduction and bowel regularity.

Compound#7· strong

Psyllium Husk

Viscous soluble fiber — lowers cholesterol, glucose, and supports regularity.

Mineral#8· strong

Magnesium Glycinate

Chelated magnesium bound to glycine — best-tolerated form for sleep, calm, and muscle relaxation.

Amino Acid#9· strong

L-Leucine

Essential BCAA and primary anabolic signaler via mTORC1 activation.

Compound#10· strong

Myo-Inositol

Insulin sensitizer used for PCOS and anxiety/OCD support.

Compound#11· strong

Betaine Anhydrous (TMG)

Methyl donor — improves power output and lowers homocysteine.

Compound#12· strong

Berberine (Glucose Use)

AMPK activator with metformin-comparable glucose-lowering effects.

Compound#13· strong

Creatine Monohydrate

Gold-standard creatine form — the most studied supplement in sports science.

Compound#14· strong

Glucomannan (Konjac)

Viscous soluble fiber that promotes satiety and lowers LDL.

Compound#15· strong

Capsaicin

Chili pepper compound that mildly increases thermogenesis and reduces appetite.

Amino Acid#16· strong

Beta-Alanine

Carnosine precursor buffering muscle pH during high-intensity work (60–240 sec).

Compound#17· strong

Alpha-Lipoic Acid

Mitochondrial antioxidant studied for diabetic neuropathy and insulin sensitivity.

Amino Acid#18· strong

Beta-Alanine

Rate-limiting precursor of muscle carnosine — buffers acid during high-intensity work.

Compound#19· strong

Psyllium (Extra Profile)

Viscous fiber with strong LDL-lowering effect.

Amino Acid#20· strong

Essential Amino Acids (EAA)

Full-spectrum EAA blend providing all 9 essentials for MPS.

Compound#21· strong

ALA (R-isomer)

Natural enantiomer of α-lipoic acid with better bioavailability.

Compound#22· moderate

Berberine

Plant alkaloid that activates AMPK — metformin-like effects on glucose and lipids.

Amino Acid#23· moderate

L-Carnitine

Shuttles long-chain fatty acids into mitochondria for β-oxidation.

Herb#24· moderate

Fenugreek

Spice/herb traditionally for libido & glycemic control; modest free-T effects.

Herb#25· moderate

American Ginseng

Cooler adaptogen with stronger evidence for blood sugar and cold-flu prevention.

Herb#26· moderate

Holy Basil (Tulsi)

Ayurvedic adaptogen with anti-stress, anti-inflammatory, and glycemic effects.

Herb#27· moderate

Green Tea (EGCG)

Polyphenol-rich tea; EGCG modestly boosts metabolism and supports cardiovascular health.

Compound#28· moderate

Alpha-Lipoic Acid (ALA)

Universal antioxidant that's both water and fat soluble — supports glycemic control and nerve health.

Amino Acid#29· moderate

Citrulline Malate

NO precursor stacked with malate — improves pump and reduces post-workout soreness.

Compound#30· moderate

HMB (β-Hydroxy-β-Methylbutyrate)

Leucine metabolite — anti-catabolic, useful for cutting phases and untrained populations.

Compound#31· moderate

Myo-Inositol

Insulin-sensitizing sugar alcohol — first-line non-Rx option for PCOS.

Compound#32· moderate

Yohimbine

Alpha-2 antagonist — improves erection and fat loss in fasted state but cardiovascular caution.

Nootropic#33· moderate

Alpha-GPC

Bioavailable choline source studied for cognition and acute power output.

Amino Acid#34· moderate

BCAAs

Branched-chain amino acids — leucine is the primary mTOR signal for muscle protein synthesis.

Compound#35· moderate

HMB

Leucine metabolite reducing muscle protein breakdown, useful in untrained/elderly populations.

Herb#36· moderate

Yohimbine

Alpha-2 adrenergic antagonist used for fat loss and ED; significant cardiovascular risks.

Peptide#37· moderate

Ipamorelin

Selective GH secretagogue researched for muscle and recovery; not FDA approved.

Compound#38· moderate

Casein Protein

Slow-digesting milk protein providing sustained amino acid release, popular pre-sleep.

Amino Acid#39· moderate

EAAs (Essential Amino Acids)

All 9 essential amino acids; superior to BCAAs alone for MPS.

Herb#40· moderate

Olive Leaf Extract

Mediterranean herb with antihypertensive and immune effects.

Herb#41· moderate

Cinnamon

Common spice with modest glucose-lowering effects (cassia type studied most).

Herb#42· moderate

Gymnema Sylvestre

Herb that blocks sweet taste perception and modestly lowers glucose.

Mineral#43· moderate

Magnesium Glycinate

Bisglycinate chelate form of magnesium — gentle, well-absorbed, ideal for sleep.

Compound#44· moderate

Urolithin A

Gut-microbial metabolite of ellagitannins — induces mitophagy.

Herb#45· moderate

Holy Basil (Tulsi)

Sacred basil adaptogen — anti-stress and mild glucose-lowering effects.

Vitamin#46· moderate

Benfotiamine

Lipid-soluble thiamine derivative with superior tissue penetration — used in diabetic neuropathy.

Herb#47· moderate

Olive Leaf Extract

Polyphenol-rich leaf extract for blood pressure and glucose.

Compound#48· moderate

Akkermansia muciniphila

Mucin-degrading commensal linked to metabolic health.

Mushroom#49· moderate

Maitake D-Fraction

Standardized β-glucan from Grifola frondosa for immune support.

Herb#50· moderate

White Kidney Bean Extract

α-amylase inhibitor that lowers post-meal carbohydrate absorption.

Herb#51· moderate

Ashwagandha (Strength)

KSM-66 dose for resistance training adaptations.

Compound#52· moderate

Betaine (Strength)

Methyl donor used for power output and body composition.

Mineral#53· moderate

Vanadyl Sulfate

Trace mineral with insulin-mimetic effects studied for T2DM.

Compound#54· moderate

Stevia (Rebaudioside A)

Non-caloric sweetener that may improve glycemia and BP.

Compound#55· moderate

MK-677 (Ibutamoren) — Ref

Oral ghrelin mimetic that raises GH/IGF-1 (research reference).

Compound#56· moderate

Urolithin A (Mitopure)

Gut-derived ellagitannin metabolite that induces mitophagy.

Herb#57· moderate

Holy Basil (Tulsi)

Adaptogenic basil used for stress and blood sugar.

Peptide#58· moderate

CJC-1295

GHRH analog with extended half-life.

Amino Acid#59· moderate

L-Leucine

Branched-chain amino acid that triggers mTOR.

Herb#60· moderate

Suma Root

Brazilian ginseng adaptogen.

Amino Acid#61· moderate

EAA Blend (Essential Amino Acids)

Complete essential amino blend.

Amino Acid#62· moderate

BCAA 2:1:1

Leucine:Isoleucine:Valine for muscle.

Amino Acid#63· moderate

Leucine (Mono)

Pure leucine for mTOR.

Amino Acid#64· moderate

L-Valine

BCAA for endurance.

Compound#65· moderate

HMB-Free Acid

Faster-absorbing HMB form.

Compound#66· moderate

Buffered Creatine (Kre-Alkalyn)

pH-buffered creatine.

Compound#67· moderate

Creatine Ethyl Ester

Ester form of creatine.

Fatty Acid#68· moderate

Arachidonic Acid

Omega-6 for muscle inflammation signaling.

Compound#69· moderate

(−)-Epicatechin

Cocoa flavanol for follistatin/myostatin.

Compound#70· moderate

5α-Hydroxy Laxogenin

Plant spirostan for muscle.

Compound#71· moderate

Turkesterone

Ajuga turkestanica ecdysteroid.

Compound#72· moderate

20-Hydroxyecdysone

Spinach ecdysteroid.

Compound#73· moderate

Whey Protein Isolate

Highly bioavailable protein.

Compound#74· moderate

Micellar Casein

Slow-digesting milk protein.

Compound#75· moderate

Egg White Protein

Highest PDCAAS plant-free protein.

Compound#76· moderate

Pea Protein Isolate

Plant-based protein.

Compound#77· moderate

Brown Rice Protein

Hypoallergenic plant protein.

Compound#78· moderate

Hemp Protein

Cannabis sativa seed protein.

Mineral#79· limited

Chromium

Trace mineral marketed for blood sugar control and carbohydrate cravings.

Amino Acid#80· limited

5-HTP

Direct serotonin precursor with mood and sleep applications.

Herb#81· limited

Gymnema Sylvestre

Sugar-blocking herb (gymnemic acid) used for cravings and post-prandial glucose.

Mineral#82· limited

Magnesium Taurate

Magnesium + taurine — gentle on the gut with cardiovascular and glycemic synergies.

Mineral#83· limited

Magnesium Malate

Magnesium + malic acid — favored for daytime energy and fibromyalgia-related fatigue.

Mineral#84· limited

Magnesium Chloride

Topical and oral magnesium with good absorption — commonly used in 'magnesium oil' sprays.

Compound#85· limited

Creatine HCl

Hydrochloride salt of creatine — more water-soluble, marketed for less bloating.

Amino Acid#86· limited

Creatine HCl

Alternative creatine form marketed for higher solubility; efficacy equivalent to monohydrate per gram active creatine.

Herb#87· limited

Yerba Mate

South American caffeine-containing tea with saponin and chlorogenic acid content.

Herb#88· limited

Bitter Melon

Traditional anti-diabetic; modest glucose-lowering and weight-loss effects.

Compound#89· limited

Fucoxanthin

Brown seaweed carotenoid studied for visceral fat reduction.

Herb#90· limited

Garcinia Cambogia (HCA)

Hydroxycitric acid supplement marketed for weight loss; weak clinical evidence.

Compound#91· limited

Pterostilbene

Methylated analog of resveratrol — better bioavailability and longer half-life.

Herb#92· limited

Bitter Melon

Plant insulin analog (charantin, polypeptide-p) for glycemic control.

Compound#93· limited

Deer Antler Velvet

IGF-1-containing traditional preparation marketed for recovery.

Compound#94· limited

Alpha-Ketoglutarate (AKG)

TCA-cycle intermediate studied for healthspan and frailty.

Compound#95· limited

Phosphatidic Acid

Phospholipid activator of mTORC1 marketed for hypertrophy.

Compound#96· limited

(-)-Epicatechin

Cocoa flavanol that suppresses myostatin and improves NO.

Compound#97· limited

Ursolic Acid

Apple-peel triterpene with anabolic and lipolytic effects in rodents.

Herb#98· limited

Rhaponticum Carthamoides

Russian adaptogen with ecdysteroid content for performance.

Compound#99· limited

Ecdysterone (Isolated)

Spinach/Rhaponticum-derived steroid with anabolic claims.

Compound#100· limited

Dihydroberberine

Reduced form of berberine with 5× greater oral bioavailability.