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evidence · mechanism · dose
Supplements/Amino Acid

Citrulline Malate

NO precursor stacked with malate — improves pump and reduces post-workout soreness.

Athletic PerformanceMuscle Growth

Overview

NO precursor stacked with malate — improves pump and reduces post-workout soreness.

Natural sources
    Common forms

      Mechanism of action

      Citrulline → arginine → NO; malate enters TCA cycle.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves reps to failure

        Moderate evidence

        Reduces DOMS

        Moderate evidence

        Potential side effects

        Common
        • · GI distress at high dose
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            6–8 g 30–60 min pre-workout
            With food?
            Optional

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (9)

            RCTJ Strength Cond Res · 2010

            Citrulline malate on resistance exercise performance

            Pérez-Guisado J, Jakeman PM

            Crossover trial of 8 g CM before resistance exercise.

            Key findings

            Increased reps and reduced soreness.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Citrulline Malate — Improves reps to failure

            Live PubMed search

            Live results for "Citrulline Malate Improves reps to failure" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Citrulline Malate and "Improves reps to failure". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Citrulline Malate — Reduces DOMS

            Live PubMed search

            Live results for "Citrulline Malate Reduces DOMS" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Citrulline Malate and "Reduces DOMS". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Citrulline Malate — randomized controlled trial

            Live PubMed search

            Live results for "Citrulline Malate randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Citrulline Malate and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Citrulline Malate — meta-analysis

            Live PubMed search

            Live results for "Citrulline Malate meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Citrulline Malate and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Citrulline Malate — pharmacokinetics

            Live PubMed search

            Live results for "Citrulline Malate pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Citrulline Malate and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Citrulline Malate — safety adverse events

            Live PubMed search

            Live results for "Citrulline Malate safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Citrulline Malate and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Citrulline Malate — dose response

            Live PubMed search

            Live results for "Citrulline Malate dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Citrulline Malate and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Citrulline Malate — clinical evidence

            Live Scholar search

            Cross-database citation index for Citrulline Malate as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.