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evidence · mechanism · dose
Supplements/Amino Acid

L-Valine

BCAA for endurance.

Athletic PerformanceMuscle Growth

Overview

BCAA for endurance.

Natural sources
    Common forms

      Mechanism of action

      Energy substrate during exercise.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Endurance support

        Moderate evidence

        Potential side effects

        Common
        • · Well tolerated
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            2–5 g

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Amino Acid
            L-Valine
            Amazon
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            Amino Acid
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            iHerb
            Global delivery · curated brands
            Amino Acid
            L-Valine
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            Systematic reviewJ Nutr · 2006

            Valine and central fatigue

            Blomstrand E

            Mechanistic review

            Key findings

            May reduce central fatigue.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Valine — Endurance support

            Live PubMed search

            Live results for "L-Valine Endurance support" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Valine and "Endurance support". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Valine — randomized controlled trial

            Live PubMed search

            Live results for "L-Valine randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Valine and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Valine — meta-analysis

            Live PubMed search

            Live results for "L-Valine meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Valine and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Valine — pharmacokinetics

            Live PubMed search

            Live results for "L-Valine pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Valine and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Valine — safety adverse events

            Live PubMed search

            Live results for "L-Valine safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Valine and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Valine — dose response

            Live PubMed search

            Live results for "L-Valine dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Valine and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: L-Valine — clinical evidence

            Live Scholar search

            Cross-database citation index for L-Valine as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.