Overview
Phospholipid activator of mTORC1 marketed for hypertrophy.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Direct allosteric activator of mTORC1; enhances translation of muscle proteins.
- · Direct allosteric activator of mTORC1
- · enhances translation of muscle proteins
Effects on the body
Organ system effects
Phosphatidic Acid influences muscle protein synthesis, neuromuscular output, or recovery from exercise.
Evidence-based benefits
Modest hypertrophy benefit in trained men
Limited evidencePotential side effects
- · Phosphatidic Acid is generally well-tolerated at evidence-based doses
- · Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
- · Headache or transient fatigue reported by a small fraction of users
- · Allergic or hypersensitivity reaction (rash, itching, swelling)
- · Sleep disturbance if taken late in the day
- · Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing
Drug interactions
Supplement interactions
- Creatine monohydrateFoundational support for strength, power, and lean mass.
- Whey or EAAsProvides amino acid substrate for muscle protein synthesis.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Phosphatidic Acid — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Phosphatidic Acid third party tested NSF
CapsulesPre-measured Phosphatidic Acid capsules — easiest for travel and consistent daily dosing without scoops or scales.Phosphatidic Acid capsules
PowderBulk unflavored Phosphatidic Acid powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Phosphatidic Acid powder unflavored
Best sellersMost-purchased Phosphatidic Acid products on Amazon — a quick way to see what's reviewed widely before you commit.Phosphatidic Acid best sellerScientific evidence8Show studiesHide studies
Phosphatidic acid on hypertrophy
Joy JM, et al.
8-week DB-RCT in 28 resistance-trained men.
Greater lean mass and strength vs placebo.
PubMed: Phosphatidic Acid — Modest hypertrophy benefit in trained men
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PubMed: Phosphatidic Acid — randomized controlled trial
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PubMed: Phosphatidic Acid — dose response
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Google Scholar: Phosphatidic Acid — clinical evidence
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