SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Compound

Phosphatidic Acid

Phospholipid activator of mTORC1 marketed for hypertrophy.

Muscle Growth

Overview

Phospholipid activator of mTORC1 marketed for hypertrophy.

Natural sources
    Common forms

      Mechanism of action

      Direct allosteric activator of mTORC1; enhances translation of muscle proteins.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Modest hypertrophy benefit in trained men

        Limited evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              750 mg pre-workout

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Compound
              Phosphatidic…
              Amazon
              Wide selection · fast shipping
              Compound
              Phosphatidic…
              iHerb
              Global delivery · curated brands
              Compound
              Phosphatidic…
              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              RCTNutr Metab (Lond) · 2014

              Phosphatidic acid on hypertrophy

              Joy JM, et al.

              8-week DB-RCT in 28 resistance-trained men.

              Key findings

              Greater lean mass and strength vs placebo.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Phosphatidic Acid — Modest hypertrophy benefit in trained men

              Live PubMed search

              Live results for "Phosphatidic Acid Modest hypertrophy benefit in trained men" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Phosphatidic Acid and "Modest hypertrophy benefit in trained men". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Phosphatidic Acid — randomized controlled trial

              Live PubMed search

              Live results for "Phosphatidic Acid randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Phosphatidic Acid and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Phosphatidic Acid — meta-analysis

              Live PubMed search

              Live results for "Phosphatidic Acid meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Phosphatidic Acid and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Phosphatidic Acid — pharmacokinetics

              Live PubMed search

              Live results for "Phosphatidic Acid pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Phosphatidic Acid and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Phosphatidic Acid — safety adverse events

              Live PubMed search

              Live results for "Phosphatidic Acid safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Phosphatidic Acid and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Phosphatidic Acid — dose response

              Live PubMed search

              Live results for "Phosphatidic Acid dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Phosphatidic Acid and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: Phosphatidic Acid — clinical evidence

              Live Scholar search

              Cross-database citation index for Phosphatidic Acid as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.