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Supplements/Compound

5α-Hydroxy Laxogenin

Plant spirostan for muscle.

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Overview

Plant spirostan for muscle.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Mechanism of action

Anabolic ratio enhancement (claims).

Pathways
  • · Anabolic ratio enhancement (claims)

Effects on the body

Supports
Limited human data

Organ system effects

Skeletal Muscle

5α-Hydroxy Laxogenin influences muscle protein synthesis, neuromuscular output, or recovery from exercise.

Evidence-based benefits

Limited human data

Moderate evidence

Potential side effects

Common
  • · Unknown
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose 5α-Hydroxy Laxogenin use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Supplement interactions

      Pairs well with
      • Creatine monohydrate
        Foundational support for strength, power, and lean mass.
      • Whey or EAAs
        Provides amino acid substrate for muscle protein synthesis.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      100 mg
      Best form
      Most evidence is based on the capsule or softgel form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      With a meal containing fat for fat-soluble compounds; otherwise either.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      AnimalEksp Klin Farmakol · 2000

      Laxogenin animal

      Syrov VN

      Rat models

      Key findings

      Anabolic effects in rats.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: 5α-Hydroxy Laxogenin — Limited human data

      Live PubMed search

      Live results for "5α-Hydroxy Laxogenin Limited human data" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching 5α-Hydroxy Laxogenin and "Limited human data". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: 5α-Hydroxy Laxogenin — randomized controlled trial

      Live PubMed search

      Live results for "5α-Hydroxy Laxogenin randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching 5α-Hydroxy Laxogenin and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: 5α-Hydroxy Laxogenin — meta-analysis

      Live PubMed search

      Live results for "5α-Hydroxy Laxogenin meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching 5α-Hydroxy Laxogenin and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: 5α-Hydroxy Laxogenin — pharmacokinetics

      Live PubMed search

      Live results for "5α-Hydroxy Laxogenin pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching 5α-Hydroxy Laxogenin and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: 5α-Hydroxy Laxogenin — safety adverse events

      Live PubMed search

      Live results for "5α-Hydroxy Laxogenin safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching 5α-Hydroxy Laxogenin and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: 5α-Hydroxy Laxogenin — dose response

      Live PubMed search

      Live results for "5α-Hydroxy Laxogenin dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching 5α-Hydroxy Laxogenin and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: 5α-Hydroxy Laxogenin — clinical evidence

      Live Scholar search

      Cross-database citation index for 5α-Hydroxy Laxogenin as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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