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Rhaponticum Carthamoides

aka Leuzea

Russian adaptogen with ecdysteroid content for performance.

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Overview

Russian adaptogen with ecdysteroid content for performance.

Natural sources
  • Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
  • Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
  • Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
Common forms
  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Mechanism of action

20-hydroxyecdysone modulates ER-β and mTOR.

Pathways
  • · 20-hydroxyecdysone modulates ER-β

Effects on the body

Supports
work capacity and strength in small trials

Organ system effects

Skeletal Muscle

Rhaponticum Carthamoides influences muscle protein synthesis, neuromuscular output, or recovery from exercise.

Evidence-based benefits

Improves work capacity and strength in small trials

Limited evidence

Potential side effects

Common
  • · Rhaponticum Carthamoides is generally well-tolerated at evidence-based doses
  • · Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
  • · Headache or transient fatigue reported by a small fraction of users
Rare
  • · Allergic or hypersensitivity reaction (rash, itching, swelling)
  • · Sleep disturbance if taken late in the day
Serious
  • · Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing

Drug interactions

Prescription medications (general)
Always disclose Rhaponticum Carthamoides use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
minor

Safety & non-supplemental interactions

Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

Avoid if you are
  • ·Pregnant or breastfeeding (insufficient safety data)
  • ·Children under 18 (unless directed by a clinician)

Supplement interactions

Pairs well with
  • Creatine monohydrate
    Foundational support for strength, power, and lean mass.
  • Whey or EAAs
    Provides amino acid substrate for muscle protein synthesis.
Avoid combining with

No specific avoidances listed.

Dosing & bioavailability

Typical dose
100–500 mg extract
Best form
Most evidence is based on the standardized extract capsule form.
Timing
Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
With food?
Morning

Where to buy

Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

Scientific evidence8Show studies
RCTArch Toxicol · 2019

Ecdysteroids in resistance training

Isenmann E, et al.

10-week DB-RCT in 46 resistance-trained men.

Key findings

Greater muscle mass in ecdysterone group.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: Rhaponticum Carthamoides — Improves work capacity and strength in small trials

Live PubMed search

Live results for "Rhaponticum Carthamoides Improves work capacity and strength in small trials" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching Rhaponticum Carthamoides and "Improves work capacity and strength in small trials". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: Rhaponticum Carthamoides — randomized controlled trial

Live PubMed search

Live results for "Rhaponticum Carthamoides randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching Rhaponticum Carthamoides and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: Rhaponticum Carthamoides — meta-analysis

Live PubMed search

Live results for "Rhaponticum Carthamoides meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching Rhaponticum Carthamoides and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: Rhaponticum Carthamoides — pharmacokinetics

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Live results for "Rhaponticum Carthamoides pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

Key findings

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Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: Rhaponticum Carthamoides — safety adverse events

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Live results for "Rhaponticum Carthamoides safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

Key findings

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Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: Rhaponticum Carthamoides — dose response

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Live results for "Rhaponticum Carthamoides dose response" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching Rhaponticum Carthamoides and "dose response". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewGoogle Scholar · 1970

Google Scholar: Rhaponticum Carthamoides — clinical evidence

Live Scholar search

Cross-database citation index for Rhaponticum Carthamoides as it relates to "clinical evidence".

Key findings

Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

Open study
Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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