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evidence · mechanism · dose
Supplements/Herb

Rhaponticum Carthamoides

aka Leuzea

Russian adaptogen with ecdysteroid content for performance.

Muscle Growth

Overview

Russian adaptogen with ecdysteroid content for performance.

Natural sources
    Common forms

      Mechanism of action

      20-hydroxyecdysone modulates ER-β and mTOR.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves work capacity and strength in small trials

        Limited evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Safety & non-supplemental interactions

              Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

              Avoid if you are
              • ·Pregnant or breastfeeding (insufficient safety data)
              • ·Children under 18 (unless directed by a clinician)

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              100–500 mg extract
              With food?
              Morning

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Herb
              Rhaponticum …
              Amazon
              Wide selection · fast shipping
              Herb
              Rhaponticum …
              iHerb
              Global delivery · curated brands
              Herb
              Rhaponticum …
              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              RCTArch Toxicol · 2019

              Ecdysteroids in resistance training

              Isenmann E, et al.

              10-week DB-RCT in 46 resistance-trained men.

              Key findings

              Greater muscle mass in ecdysterone group.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Rhaponticum Carthamoides — Improves work capacity and strength in small trials

              Live PubMed search

              Live results for "Rhaponticum Carthamoides Improves work capacity and strength in small trials" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Rhaponticum Carthamoides and "Improves work capacity and strength in small trials". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Rhaponticum Carthamoides — randomized controlled trial

              Live PubMed search

              Live results for "Rhaponticum Carthamoides randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Rhaponticum Carthamoides and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Rhaponticum Carthamoides — meta-analysis

              Live PubMed search

              Live results for "Rhaponticum Carthamoides meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Rhaponticum Carthamoides and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Rhaponticum Carthamoides — pharmacokinetics

              Live PubMed search

              Live results for "Rhaponticum Carthamoides pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Rhaponticum Carthamoides and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Rhaponticum Carthamoides — safety adverse events

              Live PubMed search

              Live results for "Rhaponticum Carthamoides safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Rhaponticum Carthamoides and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Rhaponticum Carthamoides — dose response

              Live PubMed search

              Live results for "Rhaponticum Carthamoides dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Rhaponticum Carthamoides and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: Rhaponticum Carthamoides — clinical evidence

              Live Scholar search

              Cross-database citation index for Rhaponticum Carthamoides as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.