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Supplements/Peptide

CJC-1295

GHRH analog with extended half-life.

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Overview

GHRH analog with extended half-life.

Natural sources
  • Synthetic peptide manufactured to pharmaceutical or research-grade purity
  • Subcutaneous injection, sublingual, or oral preparation depending on bioavailability
  • Compounded by a licensed pharmacy for clinical use
Common forms
  • Subcutaneous injection
  • Oral or sublingual lozenge
  • Nasal spray
  • Compounded topical

Mechanism of action

Binds albumin via DAC for prolonged GHRH activity.

Pathways
  • · Binds albumin via DAC for prolonged GHRH activity

Effects on the body

Supports
Sustained GH and IGF-1 elevation

Organ system effects

Skeletal Muscle

CJC-1295 influences muscle protein synthesis, neuromuscular output, or recovery from exercise.

Evidence-based benefits

Sustained GH and IGF-1 elevation

Moderate evidence

Potential side effects

Common
  • · Injection site reactions
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose CJC-1295 use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Other notes
      • ·Most research peptides are not FDA-approved for human use outside investigational protocols.

      Supplement interactions

      Pairs well with
      • Creatine monohydrate
        Foundational support for strength, power, and lean mass.
      • Whey or EAAs
        Provides amino acid substrate for muscle protein synthesis.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      1–2 mg weekly
      Best form
      Most evidence is based on the subcutaneous injection form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either with or without food.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      RCTJ Clin Endocrinol Metab · 2006

      CJC-1295 GH release

      Teichman SL, et al.

      Healthy adults

      Key findings

      Sustained GH and IGF-1 elevation up to 11 days.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: CJC-1295 — Sustained GH and IGF-1 elevation

      Live PubMed search

      Live results for "CJC-1295 Sustained GH and IGF-1 elevation" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching CJC-1295 and "Sustained GH and IGF-1 elevation". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: CJC-1295 — randomized controlled trial

      Live PubMed search

      Live results for "CJC-1295 randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching CJC-1295 and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: CJC-1295 — meta-analysis

      Live PubMed search

      Live results for "CJC-1295 meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching CJC-1295 and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: CJC-1295 — pharmacokinetics

      Live PubMed search

      Live results for "CJC-1295 pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching CJC-1295 and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: CJC-1295 — safety adverse events

      Live PubMed search

      Live results for "CJC-1295 safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching CJC-1295 and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: CJC-1295 — dose response

      Live PubMed search

      Live results for "CJC-1295 dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching CJC-1295 and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: CJC-1295 — clinical evidence

      Live Scholar search

      Cross-database citation index for CJC-1295 as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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