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Supplements/Fatty Acid

Arachidonic Acid

Omega-6 for muscle inflammation signaling.

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Overview

Omega-6 for muscle inflammation signaling.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Mechanism of action

Eicosanoid precursor; mTOR activator.

Pathways
  • · Eicosanoid precursor
  • · mTOR activator

Effects on the body

Increases
muscle thickness

Organ system effects

Skeletal Muscle

Arachidonic Acid influences muscle protein synthesis, neuromuscular output, or recovery from exercise.

Evidence-based benefits

Increases muscle thickness

Moderate evidence

Potential side effects

Common
  • · Inflammation concerns
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Arachidonic Acid use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Supplement interactions

      Pairs well with
      • Creatine monohydrate
        Foundational support for strength, power, and lean mass.
      • Whey or EAAs
        Provides amino acid substrate for muscle protein synthesis.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      1.5 g
      Best form
      Most evidence is based on the capsule or softgel form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either with or without food.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      RCTJ Int Soc Sports Nutr · 2016

      ARA and resistance training

      De Souza EO, et al.

      30 men

      Key findings

      Increased lean mass.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Arachidonic Acid — Increases muscle thickness

      Live PubMed search

      Live results for "Arachidonic Acid Increases muscle thickness" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Arachidonic Acid and "Increases muscle thickness". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Arachidonic Acid — randomized controlled trial

      Live PubMed search

      Live results for "Arachidonic Acid randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Arachidonic Acid and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Arachidonic Acid — meta-analysis

      Live PubMed search

      Live results for "Arachidonic Acid meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Arachidonic Acid and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Arachidonic Acid — pharmacokinetics

      Live PubMed search

      Live results for "Arachidonic Acid pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Arachidonic Acid and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Arachidonic Acid — safety adverse events

      Live PubMed search

      Live results for "Arachidonic Acid safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Arachidonic Acid and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Arachidonic Acid — dose response

      Live PubMed search

      Live results for "Arachidonic Acid dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Arachidonic Acid and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Arachidonic Acid — clinical evidence

      Live Scholar search

      Cross-database citation index for Arachidonic Acid as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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