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evidence · mechanism · dose
Supplements/Compound

20-Hydroxyecdysone

Spinach ecdysteroid.

Muscle Growth

Overview

Spinach ecdysteroid.

Natural sources
    Common forms

      Mechanism of action

      Anabolic effects via ERβ.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Modest muscle gains

        Moderate evidence

        Potential side effects

        Common
        • · Well tolerated
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            200–800 mg

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            20-Hydroxyec…
            Amazon
            Wide selection · fast shipping
            Compound
            20-Hydroxyec…
            iHerb
            Global delivery · curated brands
            Compound
            20-Hydroxyec…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTArch Toxicol · 2019

            Ecdysterone RCT

            Isenmann E, et al.

            46 men

            Key findings

            Increased muscle and 1RM bench press.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: 20-Hydroxyecdysone — Modest muscle gains

            Live PubMed search

            Live results for "20-Hydroxyecdysone Modest muscle gains" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching 20-Hydroxyecdysone and "Modest muscle gains". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: 20-Hydroxyecdysone — randomized controlled trial

            Live PubMed search

            Live results for "20-Hydroxyecdysone randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching 20-Hydroxyecdysone and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: 20-Hydroxyecdysone — meta-analysis

            Live PubMed search

            Live results for "20-Hydroxyecdysone meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching 20-Hydroxyecdysone and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: 20-Hydroxyecdysone — pharmacokinetics

            Live PubMed search

            Live results for "20-Hydroxyecdysone pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching 20-Hydroxyecdysone and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: 20-Hydroxyecdysone — safety adverse events

            Live PubMed search

            Live results for "20-Hydroxyecdysone safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching 20-Hydroxyecdysone and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: 20-Hydroxyecdysone — dose response

            Live PubMed search

            Live results for "20-Hydroxyecdysone dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching 20-Hydroxyecdysone and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: 20-Hydroxyecdysone — clinical evidence

            Live Scholar search

            Cross-database citation index for 20-Hydroxyecdysone as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.