Overview
Spinach ecdysteroid.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Anabolic effects via ERβ.
- · Anabolic effects via ERβ
Effects on the body
Organ system effects
20-Hydroxyecdysone influences muscle protein synthesis, neuromuscular output, or recovery from exercise.
Evidence-based benefits
Modest muscle gains
Moderate evidencePotential side effects
- · Well tolerated
Drug interactions
Supplement interactions
- Creatine monohydrateFoundational support for strength, power, and lean mass.
- Whey or EAAsProvides amino acid substrate for muscle protein synthesis.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified 20-Hydroxyecdysone — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.20-Hydroxyecdysone third party tested NSF
CapsulesPre-measured 20-Hydroxyecdysone capsules — easiest for travel and consistent daily dosing without scoops or scales.20-Hydroxyecdysone capsules
PowderBulk unflavored 20-Hydroxyecdysone powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.20-Hydroxyecdysone powder unflavored
Best sellersMost-purchased 20-Hydroxyecdysone products on Amazon — a quick way to see what's reviewed widely before you commit.20-Hydroxyecdysone best sellerScientific evidence8Show studiesHide studies
Ecdysterone RCT
Isenmann E, et al.
46 men
Increased muscle and 1RM bench press.
PubMed: 20-Hydroxyecdysone — Modest muscle gains
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PubMed: 20-Hydroxyecdysone — dose response
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Google Scholar: 20-Hydroxyecdysone — clinical evidence
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