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evidence · mechanism · dose
Supplements/Compound

Ecdysterone (Isolated)

Spinach/Rhaponticum-derived steroid with anabolic claims.

Muscle GrowthAthletic Performance

Overview

Spinach/Rhaponticum-derived steroid with anabolic claims.

Natural sources
    Common forms

      Mechanism of action

      Likely ER-β agonism; some evidence for mTOR activation.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Increases lean mass with resistance training

        Limited evidence

        Potential side effects

        Common
          Rare
            Serious
            • · WADA banned

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            30–200 mg

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Ecdysterone …
            Amazon
            Wide selection · fast shipping
            Compound
            Ecdysterone …
            iHerb
            Global delivery · curated brands
            Compound
            Ecdysterone …
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTArch Toxicol · 2015

            Ecdysterone in athletes

            Parr MK, et al.

            Trial supplementing trained athletes.

            Key findings

            Anabolic effects without androgen-receptor binding.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ecdysterone (Isolated) — Increases lean mass with resistance training

            Live PubMed search

            Live results for "Ecdysterone (Isolated) Increases lean mass with resistance training" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ecdysterone (Isolated) and "Increases lean mass with resistance training". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ecdysterone (Isolated) — randomized controlled trial

            Live PubMed search

            Live results for "Ecdysterone (Isolated) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ecdysterone (Isolated) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ecdysterone (Isolated) — meta-analysis

            Live PubMed search

            Live results for "Ecdysterone (Isolated) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ecdysterone (Isolated) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ecdysterone (Isolated) — pharmacokinetics

            Live PubMed search

            Live results for "Ecdysterone (Isolated) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ecdysterone (Isolated) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ecdysterone (Isolated) — safety adverse events

            Live PubMed search

            Live results for "Ecdysterone (Isolated) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ecdysterone (Isolated) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ecdysterone (Isolated) — dose response

            Live PubMed search

            Live results for "Ecdysterone (Isolated) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ecdysterone (Isolated) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Ecdysterone (Isolated) — clinical evidence

            Live Scholar search

            Cross-database citation index for Ecdysterone (Isolated) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.