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Supplements/Compound

Ecdysterone (Isolated)

Spinach/Rhaponticum-derived steroid with anabolic claims.

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Overview

Spinach/Rhaponticum-derived steroid with anabolic claims.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Mechanism of action

Likely ER-β agonism; some evidence for mTOR activation.

Pathways
  • · Likely ER-β agonism
  • · some evidence for mTOR activation

Effects on the body

Increases
lean mass with resistance training

Organ system effects

Skeletal Muscle

Ecdysterone (Isolated) influences muscle protein synthesis, neuromuscular output, or recovery from exercise.

Evidence-based benefits

Increases lean mass with resistance training

Limited evidence

Potential side effects

Common
    Rare
      Serious
      • · WADA banned

      Drug interactions

      Prescription medications (general)
      Always disclose Ecdysterone (Isolated) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Supplement interactions

      Pairs well with
      • Creatine monohydrate
        Foundational support for strength, power, and lean mass.
      • Whey or EAAs
        Provides amino acid substrate for muscle protein synthesis.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      30–200 mg
      Best form
      Most evidence is based on the capsule or softgel form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      With a meal containing fat for fat-soluble compounds; otherwise either.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      RCTArch Toxicol · 2015

      Ecdysterone in athletes

      Parr MK, et al.

      Trial supplementing trained athletes.

      Key findings

      Anabolic effects without androgen-receptor binding.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Ecdysterone (Isolated) — Increases lean mass with resistance training

      Live PubMed search

      Live results for "Ecdysterone (Isolated) Increases lean mass with resistance training" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Ecdysterone (Isolated) and "Increases lean mass with resistance training". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Ecdysterone (Isolated) — randomized controlled trial

      Live PubMed search

      Live results for "Ecdysterone (Isolated) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Ecdysterone (Isolated) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Ecdysterone (Isolated) — meta-analysis

      Live PubMed search

      Live results for "Ecdysterone (Isolated) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Ecdysterone (Isolated) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Ecdysterone (Isolated) — pharmacokinetics

      Live PubMed search

      Live results for "Ecdysterone (Isolated) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Ecdysterone (Isolated) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Ecdysterone (Isolated) — safety adverse events

      Live PubMed search

      Live results for "Ecdysterone (Isolated) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Ecdysterone (Isolated) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Ecdysterone (Isolated) — dose response

      Live PubMed search

      Live results for "Ecdysterone (Isolated) dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Ecdysterone (Isolated) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Ecdysterone (Isolated) — clinical evidence

      Live Scholar search

      Cross-database citation index for Ecdysterone (Isolated) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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