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evidence · mechanism · dose
Supplements/Herb

Yohimbine

aka Pausinystalia johimbe

Alpha-2 adrenergic antagonist used for fat loss and ED; significant cardiovascular risks.

Fat LossLibido & Sexual Health

Overview

Alpha-2 adrenergic antagonist used for fat loss and ED; significant cardiovascular risks.

Natural sources
  • Pausinystalia johimbe bark
Common forms
  • Yohimbine HCl
  • Yohimbe bark extract

Mechanism of action

Antagonizes pre-synaptic alpha-2 adrenergic receptors, increasing NE release and lipolysis.

Pathways
  • · α2 antagonism
Neurotransmitters
  • · Norepinephrine

Effects on the body

Increases
Lipolysis (esp. stubborn fat)
Supports
Erectile function

Organ system effects

Cardiovascular

Raises HR and BP; can precipitate panic.

Evidence-based benefits

Improves stubborn fat loss when lean & fasted

Limited evidence

Improves erectile function

Moderate evidence

Potential side effects

Common
  • · Anxiety
  • · Tachycardia
  • · Hypertension
  • · Insomnia
Rare
  • · Panic attacks
Serious
  • · Hypertensive crisis
  • · Arrhythmia

Drug interactions

MAOIs / TCAs
Hypertensive crisis.
severe
Stimulants
Additive CV strain.
severe

Safety & non-supplemental interactions

Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

Avoid if you are
  • ·Pregnant or breastfeeding (insufficient safety data)
  • ·Children under 18 (unless directed by a clinician)

Supplement interactions

Pairs well with

None listed.

Avoid combining with
  • Anxiety / panic disorder
    Provokes panic.
  • Hypertension / cardiac disease
    Raises BP/HR.

Dosing & bioavailability

Typical dose
0.1–0.2 mg/kg yohimbine HCl, fasted; avoid in HTN/anxiety

Where to buy

Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

Herb
Yohimbine
Amazon
Wide selection · fast shipping
Herb
Yohimbine
iHerb
Global delivery · curated brands
Herb
Yohimbine
Thorne
Practitioner-grade · NSF tested

Scientific evidence (9)

Meta-analysisPhytomedicine · 2011

Rhodiola rosea for fatigue: a meta-analysis

Hung SK, et al.

Meta-analysis of Rhodiola for mental/physical fatigue.

Key findings

Significant reduction in fatigue and improved performance.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: Yohimbine — Improves stubborn fat loss when lean & fasted

Live PubMed search

Live results for "Yohimbine Improves stubborn fat loss when lean & fasted" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching Yohimbine and "Improves stubborn fat loss when lean & fasted". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: Yohimbine — Improves erectile function

Live PubMed search

Live results for "Yohimbine Improves erectile function" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching Yohimbine and "Improves erectile function". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: Yohimbine — randomized controlled trial

Live PubMed search

Live results for "Yohimbine randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching Yohimbine and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: Yohimbine — meta-analysis

Live PubMed search

Live results for "Yohimbine meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching Yohimbine and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: Yohimbine — pharmacokinetics

Live PubMed search

Live results for "Yohimbine pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching Yohimbine and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: Yohimbine — safety adverse events

Live PubMed search

Live results for "Yohimbine safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching Yohimbine and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: Yohimbine — dose response

Live PubMed search

Live results for "Yohimbine dose response" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching Yohimbine and "dose response". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewGoogle Scholar · 1970

Google Scholar: Yohimbine — clinical evidence

Live Scholar search

Cross-database citation index for Yohimbine as it relates to "clinical evidence".

Key findings

Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

Open study
Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.