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evidence · mechanism · dose
Supplements/Amino Acid

Leucine (Mono)

Pure leucine for mTOR.

Muscle Growth

Overview

Pure leucine for mTOR.

Natural sources
    Common forms

      Mechanism of action

      Anabolic trigger.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Stimulates MPS

        Moderate evidence

        Potential side effects

        Common
        • · Well tolerated
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            2.5–5 g

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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            Leucine (Mono)
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            Amino Acid
            Leucine (Mono)
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            Systematic reviewJ Nutr · 2016

            Leucine for sarcopenia

            Borack MS, Volpi E

            Clinical review

            Key findings

            Effective for elderly muscle preservation.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Leucine (Mono) — Stimulates MPS

            Live PubMed search

            Live results for "Leucine (Mono) Stimulates MPS" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Leucine (Mono) and "Stimulates MPS". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Leucine (Mono) — randomized controlled trial

            Live PubMed search

            Live results for "Leucine (Mono) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Leucine (Mono) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Leucine (Mono) — meta-analysis

            Live PubMed search

            Live results for "Leucine (Mono) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Leucine (Mono) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Leucine (Mono) — pharmacokinetics

            Live PubMed search

            Live results for "Leucine (Mono) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Leucine (Mono) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Leucine (Mono) — safety adverse events

            Live PubMed search

            Live results for "Leucine (Mono) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Leucine (Mono) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Leucine (Mono) — dose response

            Live PubMed search

            Live results for "Leucine (Mono) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Leucine (Mono) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Leucine (Mono) — clinical evidence

            Live Scholar search

            Cross-database citation index for Leucine (Mono) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.