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Supplements/Amino Acid

Leucine (Mono)

Pure leucine for mTOR.

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Overview

Pure leucine for mTOR.

Natural sources
  • Dietary protein from animal sources (meat, fish, eggs, dairy) and plant sources (soy, legumes, grains)
  • Free-form amino acid powders and capsules
  • Targeted pre-workout, recovery, or sleep formulations
Common forms
  • Free-form crystalline powder
  • Capsules or tablets
  • Pre-mixed recovery or hydration beverages
  • Time-release formulations

Mechanism of action

Anabolic trigger.

Pathways
  • · Anabolic trigger

Effects on the body

Supports
Stimulates MPS

Organ system effects

Skeletal Muscle

Leucine (Mono) influences muscle protein synthesis, neuromuscular output, or recovery from exercise.

Evidence-based benefits

Stimulates MPS

Moderate evidence

Potential side effects

Common
  • · Well tolerated
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Leucine (Mono) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Supplement interactions

      Pairs well with
      • Creatine monohydrate
        Foundational support for strength, power, and lean mass.
      • Whey or EAAs
        Provides amino acid substrate for muscle protein synthesis.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      2.5–5 g
      Best form
      Most evidence is based on the free-form crystalline powder form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either with or without food.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      Systematic reviewJ Nutr · 2016

      Leucine for sarcopenia

      Borack MS, Volpi E

      Clinical review

      Key findings

      Effective for elderly muscle preservation.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Leucine (Mono) — Stimulates MPS

      Live PubMed search

      Live results for "Leucine (Mono) Stimulates MPS" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Leucine (Mono) and "Stimulates MPS". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Leucine (Mono) — randomized controlled trial

      Live PubMed search

      Live results for "Leucine (Mono) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Leucine (Mono) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Leucine (Mono) — meta-analysis

      Live PubMed search

      Live results for "Leucine (Mono) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Leucine (Mono) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Leucine (Mono) — pharmacokinetics

      Live PubMed search

      Live results for "Leucine (Mono) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Leucine (Mono) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Leucine (Mono) — safety adverse events

      Live PubMed search

      Live results for "Leucine (Mono) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Leucine (Mono) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Leucine (Mono) — dose response

      Live PubMed search

      Live results for "Leucine (Mono) dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Leucine (Mono) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Leucine (Mono) — clinical evidence

      Live Scholar search

      Cross-database citation index for Leucine (Mono) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

      Community discussion

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