SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Compound

Ursolic Acid

Apple-peel triterpene with anabolic and lipolytic effects in rodents.

Muscle Growth

Overview

Apple-peel triterpene with anabolic and lipolytic effects in rodents.

Natural sources
    Common forms

      Mechanism of action

      Suppresses atrophy genes and stimulates IGF-1/Akt signaling.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Increases lean mass in untrained mice

        Limited evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            150 mg tid
            With food?
            With food

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Ursolic Acid
            Amazon
            Wide selection · fast shipping
            Compound
            Ursolic Acid
            iHerb
            Global delivery · curated brands
            Compound
            Ursolic Acid
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            AnimalCell Metab · 2011

            Ursolic acid in mice

            Kunkel SD, et al.

            Mice given ursolic acid + atrophic insult.

            Key findings

            Reduced muscle atrophy and improved glucose tolerance.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ursolic Acid — Increases lean mass in untrained mice

            Live PubMed search

            Live results for "Ursolic Acid Increases lean mass in untrained mice" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ursolic Acid and "Increases lean mass in untrained mice". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ursolic Acid — randomized controlled trial

            Live PubMed search

            Live results for "Ursolic Acid randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ursolic Acid and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ursolic Acid — meta-analysis

            Live PubMed search

            Live results for "Ursolic Acid meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ursolic Acid and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ursolic Acid — pharmacokinetics

            Live PubMed search

            Live results for "Ursolic Acid pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ursolic Acid and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ursolic Acid — safety adverse events

            Live PubMed search

            Live results for "Ursolic Acid safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ursolic Acid and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ursolic Acid — dose response

            Live PubMed search

            Live results for "Ursolic Acid dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ursolic Acid and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Ursolic Acid — clinical evidence

            Live Scholar search

            Cross-database citation index for Ursolic Acid as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.