Supplement Scholar
Goal area

Heart & Circulation

Pressure, lipids, blood flow, and vascular health.

88 profiles, most-studied first
Mg

Magnesium

Essential cofactor in 300+ enzymatic reactions, from ATP production to muscle relaxation.

Mineral12 studies
C60H92O6

Omega-3 (EPA/DHA)

Marine long-chain omega-3s — the most-studied anti-inflammatory and cardiovascular nutrient.

Fatty Acid11 studies
C20H18NO4+

Berberine

Plant alkaloid that activates AMPK — metformin-like effects on glucose and lipids.

Compound10 studies
C59H90O4

Coenzyme Q10

Mitochondrial electron carrier and lipid-soluble antioxidant.

Compound10 studies
C46H64O2

Vitamin K2 (MK-7)

Activates the proteins that direct calcium into bone — not arteries.

Vitamin10 studies
C25H24O12

Artichoke Leaf Extract

Choleretic herb — supports bile flow, gallbladder, and mild lipid lowering.

Herb9 studies
C24H26N2O13

Beetroot Juice

Dietary nitrate source improving NO production, BP, and endurance performance.

Compound9 studies
C18H32O16

Beta-Glucan

Polysaccharide that primes innate immune cells (yeast) or lowers cholesterol (oat).

Compound9 studies
C5H11NO2

Betaine Anhydrous (TMG)

Methyl donor — improves power output and lowers homocysteine.

Compound9 studies
C21H21O11+

Bilberry

Anthocyanin-rich berry traditionally used for night vision and vascular support.

Herb9 studies
C6H10OS2

Garlic

Culinary bulb with cardiovascular benefits primarily via allicin and aged-garlic compounds.

Herb9 studies
C22H18O11

Green Tea (EGCG)

Polyphenol-rich tea; EGCG modestly boosts metabolism and supports cardiovascular health.

Herb9 studies
C21H28O2

Guggul (Commiphora mukul)

Ayurvedic resin used historically for cholesterol and thyroid support.

Herb9 studies
C6H14N4O2

L-Arginine

Conditionally essential amino acid and direct nitric oxide precursor.

Amino Acid9 studies
C6H14N4O2

L-Arginine (GH Pulse)

Stimulates a transient growth hormone pulse when taken on an empty stomach.

Amino Acid9 studies
C6H13N3O3

L-Citrulline

Arginine precursor with superior bioavailability for NO and pump-driven performance.

Amino Acid9 studies
C6H13N3O3

L-Citrulline (NO Production)

Arginine precursor — most efficient way to raise plasma arginine and NO.

Amino Acid9 studies
C48H28O30

Pomegranate

Polyphenol-rich fruit converted by gut microbes to urolithin A (mitochondrial benefit).

Herb9 studies
K

Potassium

Major intracellular cation essential for BP control, muscle function, and acid-base balance.

Mineral9 studies

Psyllium Husk

Soluble fiber with strong evidence for cholesterol reduction and bowel regularity.

Compound9 studies
C15H10O5

Soy Isoflavones

Phytoestrogens with mild SERM effects on bone, hot flashes, and lipids.

Compound9 studies
C2H7NO3S

Taurine

Conditionally essential amino acid involved in bile salt conjugation, osmoregulation, and cardiac function.

Amino Acid9 studies
C6H5NO2

Vitamin B3 (Niacin)

NAD+ precursor; nicotinic acid form lowers LDL and raises HDL.

Vitamin9 studies
C29H50O2

Vitamin E

Primary lipid-phase antioxidant protecting membrane PUFAs.

Vitamin9 studies
C15H14O6

(−)-Epicatechin

Cocoa flavanol for follistatin/myostatin.

Compound8 studies
C28H34O15

2S-Hesperidin (Cardiose)

Bioactive isomer of hesperidin.

Compound8 studies
C6H10OS2

Aged Garlic Extract (Kyolic)

Standardized aged garlic — modest BP and cholesterol benefits.

Herb8 studies
C22H32O2

Algae Omega-3

Vegan EPA/DHA source.

Fatty Acid8 studies
C22H32O2

Algal Omega-3 (Vegan EPA/DHA)

Plant-based EPA and DHA from microalgae for vegan diets.

Fatty Acid8 studies
C6H10O7

Apple Pectin

Soluble fiber from apples.

Compound8 studies
C30H48O5

Arjuna

Terminalia arjuna bark for cardiovascular support.

Herb8 studies
C25H24O12

Artichoke Leaf

Cholagogue herb improving dyspepsia and modestly reducing cholesterol.

Herb8 studies
C24H26N2O13

Beetroot Nitrate

Inorganic nitrate for NO production.

Compound8 studies
C34H42O19

Bergamot Extract

Standardized citrus polyphenol fraction shown to lower LDL and triglycerides.

Herb8 studies
C34H42O19

Bergamot Extract

Citrus bergamia for cardiometabolic support.

Herb8 studies
C29H50O

Beta-Sitosterol

Plant sterol for BPH and cholesterol.

Compound8 studies
C10H12O2

Black Seed Oil (Nigella sativa)

Thymoquinone for immune and metabolic health.

Fatty Acid8 studies
C27H42O4

Butcher's Broom

Ruscus aculeatus for venous insufficiency.

Herb8 studies
C30H48O5

Centella Triterpene Fraction

Standardized madecassoside/asiaticoside for skin and venous health.

Herb8 studies
C18H30O2

Chia Seed

Salvia hispanica ALA source.

Compound8 studies
C28H32O15

Diosmin + Hesperidin

Citrus flavonoid pair for venous insufficiency.

Compound8 studies
C20H30O2

EPA-Dominant Fish Oil

Concentrated EPA for inflammation.

Fatty Acid8 studies
C17H20O5

EVOO Polyphenols

Extra virgin olive oil polyphenols.

Fatty Acid8 studies
C30H26O12

Enzogenol

New Zealand pine bark extract.

Compound8 studies
C18H30O2

Flax Seed Oil (ALA)

Alpha-linolenic acid omega-3.

Fatty Acid8 studies
C20H24O10

Ginkgo Biloba EGb 761

Standardized Ginkgo for cognition.

Herb8 studies
C30H26O12

Grape Seed Extract

Vitis vinifera procyanidins.

Compound8 studies
C21H20O10

Hawthorn

Cardiotonic herb traditionally used for mild heart failure and mild hypertension.

Herb8 studies
C21H20O10

Hawthorn Berry

Crataegus for mild heart failure and BP support.

Herb8 studies
C18H32O2

Hemp Seed Oil

3:1 omega-6 to omega-3 ratio.

Fatty Acid8 studies
C6H8O8

Hibiscus Tea

Anthocyanin-rich tea with ACE-inhibitor-like blood pressure effects.

Herb8 studies
C55H86O24

Horse Chestnut

Aesculus seed extract for chronic venous insufficiency.

Herb8 studies
C8H10O3

Hydroxytyrosol

Olive polyphenol for cardiovascular health.

Compound8 studies
C42H30N6O12

Inositol Hexanicotinate (No-Flush Niacin)

Niacin form without flushing.

Vitamin8 studies
C21H20O12

Isoquercetin

Highly bioavailable quercetin glycoside.

Compound8 studies
C20H30O2

Krill Oil

Phospholipid-bound omega-3 with astaxanthin; better bioavailability than fish oil per gram.

Fatty Acid8 studies

Lumbrokinase

Earthworm-derived fibrinolytic enzyme complex.

Compound8 studies
C40H56

Lycopene

Tomato carotenoid linked with prostate and cardiovascular protection.

Compound8 studies
C38H47O7PS

MitoQ

Mitochondria-targeted ubiquinone (CoQ10 analog).

Compound8 studies

Nattokinase

Fermented soy serine protease with fibrinolytic activity.

Compound8 studies
C6H5NO2

Niacin Extended Release

Slow-release nicotinic acid for cholesterol.

Vitamin8 studies
C25H32O13

Olive Leaf (Standardized Oleuropein)

High-oleuropein extract.

Herb8 studies
C25H32O13

Olive Leaf Extract

Mediterranean herb with antihypertensive and immune effects.

Herb8 studies
C24H36O5

Oyster Mushroom

Pleurotus ostreatus with ergothioneine.

Mushroom8 studies
C18H30O2

Perilla Oil

High ALA from Perilla frutescens.

Fatty Acid8 studies
C29H50O

Phytosterols (Plant Sterols)

Plant sterols/stanols competitively inhibit cholesterol absorption.

Compound8 studies
C29H50O

Plant Sterols/Stanols

Phytosterols for cholesterol lowering.

Compound8 studies
C28H58O

Policosanol

Long-chain alcohols from sugarcane wax marketed for cholesterol; Cuban studies positive but unreplicated.

Compound8 studies
C48H28O30

Pomegranate Extract

Punica granatum ellagitannins.

Compound8 studies

Psyllium Husk

Soluble fiber from Plantago ovata.

Compound8 studies
C16H16O3

Pterostilbene

Bioavailable resveratrol analog with longer half-life.

Compound8 studies
C48H28O30

Punicalagin

Major pomegranate ellagitannin.

Compound8 studies
C30H26O12

Pycnogenol (Pine Bark)

French maritime pine bark for circulation.

Compound8 studies
C15H10O7

Quercetin Phytosome

Lecithin-complexed quercetin.

Compound8 studies
C24H36O5

Red Yeast Rice

Fermented rice product containing natural monacolin K (chemically identical to lovastatin).

Compound8 studies
C14H12O3

Resveratrol

Polyphenol activating sirtuins; bioavailability and clinical effects modest.

Compound8 studies
C27H30O16

Rutin

Quercetin-rutinoside for venous health.

Compound8 studies
C32H49N9O5

SS-31 (Elamipretide)

Mitochondrial-targeted peptide for cardiolipin protection.

Peptide8 studies
C22H32O2

Salmon Roe Phospholipids

Phospholipid omega-3s from salmon eggs.

Fatty Acid8 studies
C9H11N5O4

Shiitake (Lentinan)

Culinary mushroom whose beta-glucan lentinan is an approved injectable immune adjunct.

Mushroom8 studies
C30H50

Squalene

Olive oil/shark liver lipid antioxidant.

Fatty Acid8 studies
C5H11NO2

TMG (Betaine Anhydrous)

Methyl donor for homocysteine reduction.

Compound8 studies
C14H12O3

Trans-Resveratrol

Active form of resveratrol.

Compound8 studies
C5H11NO2

Trimethylglycine (Betaine)

Same as TMG; osmolyte and methyl donor.

Compound8 studies
C10H16N2O4

Type III Collagen

Skin and vascular collagen.

Compound8 studies
C27H44O

Vitamin D3 + K2

Synergistic combo for calcium routing.

Compound8 studies
C27H44O

Vitamin D3 + K2 Synergy Note

Combined fat-soluble vitamins addressing calcium destination (bone vs artery).

Vitamin8 studies
C31H46O2

Vitamin K1 (Phylloquinone)

Leafy-green K1 essential for hepatic coagulation factors.

Vitamin8 studies