Supplement Scholar
Compound

Resveratrol

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Resveratrol. Polyphenol activating sirtuins; bioavailability and clinical effects modest.

How it works. Activates SIRT1 (debated); modulates AMPK and antioxidant pathways.

What the research supports. 1 graded claims. Strongest: Mild improvement in endothelial function & insulin sensitivity (moderate).

How much to take. Typical dose: 150–500 mg/d.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Pterostilbene.

Forms. 1 forms. Pick one to open its profile.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Resveratrol. Anecdotes are not medical advice.

Resveratrol. Polyphenol activating sirtuins; bioavailability and clinical effects modest.

Molecular structureC14H12O3 · 228.24 g/mol

What it is

Polyphenol activating sirtuins; bioavailability and clinical effects modest.

Food sources

Red wineJapanese knotweedBerries

Goals

Healthy AgingCardiovascular Health

How it works

Activates SIRT1 (debated); modulates AMPK and antioxidant pathways.

Pathways

  • SIRT1 activation
  • AMPK

Effects

  • +Endothelial function supports

What the research supports

Mild improvement in endothelial function & insulin sensitivitymoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
150–500 mg/d
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the trans-resveratrol form.
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Side effects & interactions

Common side effects

  • GI upset (high dose)

Medication interactions

Anticoagulants / CYP3A4 substratesmoderate

Antiplatelet & CYP3A4 inhibition.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

Key studies

8 studies cited in total.

Resveratrol and cardiometabolic outcomes: a meta-analysis ↗
Meta-analysis · Am J Clin Nutr · 2015

Modest improvements in fasting glucose and insulin sensitivity in T2D.

PubMed: Resveratrol — Mild improvement in endothelial function & insulin sensitivity ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Resveratrol and "Mild improvement in endothelial function & insulin sensitivity". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Resveratrol — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Resveratrol and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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