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Compound

Pterostilbene

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Pterostilbene. Bioavailable resveratrol analog with longer half-life.

How it works. Similar to resveratrol but better bioavailability and SIRT1 activation.

What the research supports. 1 graded claims. Strongest: May raise LDL at higher doses (paradox) (limited).

How much to take. Typical dose: 50–250 mg/d.

Side effects and interactions. 1 medication interaction listed. Serious: Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing.

Stacking. Pairs well with NAD+ precursor (NMN or NR), Omega-3, CoQ10.

Forms. 1 forms. Pick one to open its profile.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Pterostilbene. Anecdotes are not medical advice.

Pterostilbene. Bioavailable resveratrol analog with longer half-life.

Molecular structureC16H16O3 · 256.30 g/mol

What it is

Bioavailable resveratrol analog with longer half-life.

Food sources

BlueberriesGrapes

Goals

Healthy AgingCardiovascular Health

How it works

Similar to resveratrol but better bioavailability and SIRT1 activation.

Pathways

  • SIRT1 activation

Effects

  • +Lipid profile supports

What the research supports

May raise LDL at higher doses (paradox)limited

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
50–250 mg/d
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the pterostilbene capsule form.
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Side effects & interactions

Common side effects

  • Pterostilbene is generally well-tolerated at evidence-based doses
  • Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
  • Headache or transient fatigue reported by a small fraction of users

Serious

  • Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing

Medication interactions

Prescription medications (general)minor

Always disclose Pterostilbene use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
  • Omega-3Lowers inflammation and supports membrane integrity.
  • CoQ10Supports mitochondrial energetics in cardiac tissue.

Key studies

8 studies cited in total.

PubMed: Pterostilbene — May raise LDL at higher doses ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Pterostilbene and "May raise LDL at higher doses". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Pterostilbene — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Pterostilbene and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Pterostilbene — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Pterostilbene and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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