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Compound

Pterostilbene (Extra)

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Pterostilbene (Extra). Methylated resveratrol analog with superior bioavailability.

How it works. Activates Nrf2 and SIRT1; modulates lipid metabolism.

What the research supports. 1 graded claims. Strongest: Reduces blood pressure and LDL (moderate).

How much to take. Typical dose: 100–250 mg.

Side effects and interactions. 1 medication interaction listed. Serious: Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing.

Stacking. Pairs well with NAD+ precursor (NMN or NR), Omega-3, CoQ10.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Pterostilbene (Extra). Anecdotes are not medical advice.

Pterostilbene (Extra). Methylated resveratrol analog with superior bioavailability.

Molecular structureC16H16O3 · 256.30 g/mol

What it is

Methylated resveratrol analog with superior bioavailability.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Healthy AgingCardiovascular Health

How it works

Activates Nrf2 and SIRT1; modulates lipid metabolism.

Pathways

  • Activates Nrf2
  • modulates lipid metabolism

Effects

  • ↓blood pressure and LDL decreases

What the research supports

Reduces blood pressure and LDLmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
100–250 mg
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • Pterostilbene (Extra) is generally well-tolerated at evidence-based doses
  • Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
  • Headache or transient fatigue reported by a small fraction of users

Serious

  • Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing

Medication interactions

Prescription medications (general)minor

Always disclose Pterostilbene (Extra) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
  • Omega-3Lowers inflammation and supports membrane integrity.
  • CoQ10Supports mitochondrial energetics in cardiac tissue.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Pterostilbene (Extra) — Reduces blood pressure and LDL ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Pterostilbene (Extra) and "Reduces blood pressure and LDL". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Pterostilbene (Extra) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Pterostilbene (Extra) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Pterostilbene (Extra) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Pterostilbene (Extra) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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