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Lumbrokinase

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Lumbrokinase. Earthworm-derived fibrinolytic enzyme complex.

How it works. Directly digests fibrin and activates plasminogen; lowers blood viscosity.

What the research supports. 1 graded claims. Strongest: Improves outcomes in acute ischemic stroke (Chinese trials) (moderate).

How much to take. Typical dose: 20–60 mg (≈600,000 IU).

Side effects and interactions. 1 medication interaction listed. Serious: Bleeding risk.

Stacking. Pairs well with Omega-3, CoQ10.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Lumbrokinase. Anecdotes are not medical advice.

Lumbrokinase. Earthworm-derived fibrinolytic enzyme complex.

No single structure

What it is

Earthworm-derived fibrinolytic enzyme complex.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Cardiovascular Health

How it works

Directly digests fibrin and activates plasminogen; lowers blood viscosity.

Pathways

  • Directly digests fibrin
  • activates plasminogen
  • lowers blood viscosity

Effects

  • +outcomes in acute ischemic stroke (Chinese trials) supports

What the research supports

Improves outcomes in acute ischemic stroke (Chinese trials)moderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
20–60 mg (≈600,000 IU)
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEmpty stomach
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • GI upset

Serious

  • Bleeding risk

Medication interactions

Anticoagulantssevere

Avoid combination.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Omega-3Anti-inflammatory cardiovascular synergy.
  • CoQ10Supports mitochondrial energetics in cardiac tissue.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

Lumbrokinase in ischemic stroke ↗
Meta-analysis · Eur Neurol · 2013

Improved neurological scores vs control with acceptable bleeding profile.

PubMed: Lumbrokinase — Improves outcomes in acute ischemic stroke ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Lumbrokinase and "Improves outcomes in acute ischemic stroke". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Lumbrokinase — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Lumbrokinase and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

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