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Herb

Artichoke Leaf Extract

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Artichoke Leaf Extract. Choleretic herb — supports bile flow, gallbladder, and mild lipid lowering.

How it works. Cynarin increases bile flow and inhibits cholesterol synthesis.

What the research supports. 2 graded claims. Strongest: Improves functional dyspepsia (moderate).

How much to take. Typical dose: 320–640 mg standardized.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Milk thistle (silymarin), NAC.

Common forms. Available as Standardized extract capsule, Liquid tincture (alcohol or glycerin), Powdered whole herb, Traditional decoction or tea.

Key studies. 9 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Artichoke Leaf Extract. Anecdotes are not medical advice.

Artichoke Leaf Extract. Choleretic herb — supports bile flow, gallbladder, and mild lipid lowering.

Key compound: cynarinC25H24O12 · 516.4 g/mol

What it is

Choleretic herb — supports bile flow, gallbladder, and mild lipid lowering.

Food sources

Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice

Goals

Gallbladder HealthLiver HealthCholesterolDigestion

How it works

Cynarin increases bile flow and inhibits cholesterol synthesis.

Pathways

  • Cynarin increases bile flow
  • inhibits cholesterol synthesis

Effects

  • +functional dyspepsia supports
  • +Modest LDL reduction supports

What the research supports

Improves functional dyspepsiamoderate
Modest LDL reductionlimited

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
320–640 mg standardized
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith meals
Best formMost evidence is based on the standardized extract capsule form.
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Side effects & interactions

Medication interactions

Prescription medications (general)minor

Always disclose Artichoke Leaf Extract use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

Common forms

  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Key studies

9 studies cited in total.

PubMed: Artichoke Leaf Extract — Improves functional dyspepsia ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Artichoke Leaf Extract and "Improves functional dyspepsia". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Artichoke Leaf Extract — Modest LDL reduction ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Artichoke Leaf Extract and "Modest LDL reduction". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Artichoke Leaf Extract — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Artichoke Leaf Extract and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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