Supplement Scholar
Organ-Specific Health

Liver Health

Phase I/II detox and hepatocyte support.

30 profiles, most-studied first
C5H9NO3S

Glycine + NAC (GlyNAC)

Co-supplementation of glycine and N-acetylcysteine that restores glutathione in older adults and improves multiple hallmarks of aging.

Compound14 studies
C21H20O6

Curcumin

Yellow polyphenol from turmeric — anti-inflammatory and joint-supportive when properly bioavailable.

Herb10 studies
C5H9NO3S

N-Acetyl Cysteine (NAC)

Glutathione precursor with mucolytic, hepatoprotective, and psychiatric uses.

Amino Acid10 studies
C25H24O12

Artichoke Leaf Extract

Choleretic herb — supports bile flow, gallbladder, and mild lipid lowering.

Herb9 studies
C5H14NO+

Choline

Essential nutrient for cell membranes, methylation, and acetylcholine synthesis.

Compound9 studies
C15H12O8

Dihydromyricetin (DHM)

Flavonoid from Hovenia dulcis — accelerates alcohol clearance and blunts hangover symptoms.

Compound9 studies
C10H17N3O6S

Glutathione

Master intracellular antioxidant; oral bioavailability depends on form.

Compound9 studies
C25H22O10

Milk Thistle

Hepatoprotective herb with antioxidant and anti-fibrotic effects.

Herb9 studies
C25H22O10

Milk Thistle (Liver)

Silymarin — most-studied liver herb, used for ALD, NAFLD, and toxin protection.

Herb9 studies
C25H22O10

Milk Thistle (Silymarin)

Hepatoprotective flavonolignan — best-known liver herb, often used around alcohol exposure.

Herb9 studies
C5H9NO3S

NAC (Pre/Post Drinking Use)

Glutathione precursor — bolsters acetaldehyde detoxification before and after alcohol.

Amino Acid9 studies
C15H22N6O5S

SAMe (S-Adenosyl Methionine)

Universal methyl donor with antidepressant and liver-supportive evidence.

Compound9 studies
C6H11NOS2

Sulforaphane (Broccoli Sprout)

Most potent natural Nrf2 activator — upregulates phase II detox enzymes.

Compound9 studies
C26H45NO6S

TUDCA

Bile acid with hepatoprotective effects and ER stress reduction.

Compound9 studies
C9H17NO4

ALCAR (Pre-Drinking)

Mitochondrial cofactor that may reduce acetaldehyde-induced oxidative stress.

Amino Acid8 studies
C25H24O12

Artichoke Leaf

Cholagogue herb improving dyspepsia and modestly reducing cholesterol.

Herb8 studies
C6H10O8

Calcium D-Glucarate

Beta-glucuronidase inhibitor promoting elimination of conjugated hormones/toxins.

Compound8 studies
C9H19NO7

Choline Bitartrate

Affordable choline source — supports phospholipid synthesis and methylation.

Compound8 studies
C5H12N2O2

L-Ornithine

Urea cycle amino acid for ammonia clearance.

Amino Acid8 studies
C12H22O11

Lactulose

Non-absorbable disaccharide for constipation and HE.

Compound8 studies
Mo

Molybdenum

Trace mineral cofactor for xanthine oxidase and sulfite oxidase.

Mineral8 studies

Phosphatidylcholine

Membrane phospholipid for liver.

Compound8 studies

Phosphatidylcholine (PC)

Major brain and hepatic phospholipid often given for liver support.

Compound8 studies
C24H28O11

Picrorhiza Kurroa

Indian herb for liver protection.

Herb8 studies
C24H32O7

Schisandra

Adaptogenic berry traditionally used for stamina, liver protection, and stress resilience.

Herb8 studies
C25H22O10

Siliphos (Silybin Phytosome)

Silybin-phosphatidylcholine complex.

Herb8 studies
C25H22O10

Silybin

Most active milk thistle flavonolignan.

Compound8 studies
C25H22O10

Silymarin (Milk Thistle)

Silybum marianum flavonolignans for liver.

Herb8 studies

Soy Lecithin

Phosphatidylcholine source.

Compound8 studies
C5H11NO2

Trimethylglycine (Betaine)

Same as TMG; osmolyte and methyl donor.

Compound8 studies