Glutathione
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Glutathione. Master intracellular antioxidant; oral bioavailability depends on form.
How it works. Reduces ROS via glutathione peroxidase; conjugates xenobiotics in Phase II.
What the research supports. 2 graded claims. Strongest: Raises blood GSH with liposomal/S-acetyl (moderate).
How much to take. Typical dose: 250–1000 mg liposomal or S-acetyl.
Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.
Stacking. Pairs well with NAC + Glycine.
Forms. 2 forms. Pick one to open its profile.
Key studies. 9 studies cited. The strongest are listed with links to PubMed.
Community. Experiences from people who have tried Glutathione. Anecdotes are not medical advice.
Glutathione. Master intracellular antioxidant; oral bioavailability depends on form.
What it is
Master intracellular antioxidant; oral bioavailability depends on form.
Also called
Food sources
Goals
How it works
Reduces ROS via glutathione peroxidase; conjugates xenobiotics in Phase II.
Pathways
- Phase II conjugation
- Redox cycling
Effects
- ↑Intracellular glutathione (liposomal) increases
What the research supports
Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.
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Side effects & interactions
Medication interactions
Always disclose Glutathione use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
Check any supplement–medication combination with your pharmacist before starting.
Combines with
Pairs well
- NAC + GlycineCheaper precursors that raise GSH similarly.
Key studies
9 studies cited in total.
Opens current human and preclinical literature matching Glutathione and "Raises blood GSH with liposomal/S-acetyl". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Glutathione and "Improves NAFLD markers". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Glutathione and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
Discussion
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