Supplement Scholar
Compound

Dihydromyricetin (DHM)

Buy on Amazon ↗

Affiliate link: we may earn a commission at no extra cost to you. Disclosures

Dihydromyricetin (DHM). Flavonoid from Hovenia dulcis — accelerates alcohol clearance and blunts hangover symptoms.

How it works. Upregulates ADH and ALDH activity; blocks alcohol's potentiation of GABA-A receptors, reducing intoxication and rebound anxiety.

What the research supports. 2 graded claims. Strongest: Animal evidence for ALD prevention (moderate).

How much to take. Typical dose: 300–600 mg before drinking; repeat before bed.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with NAC, Electrolytes.

Forms. 1 forms. Pick one to open its profile.

Key studies. 9 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Dihydromyricetin (DHM). Anecdotes are not medical advice.

Dihydromyricetin (DHM). Flavonoid from Hovenia dulcis — accelerates alcohol clearance and blunts hangover symptoms.

Molecular structureC15H12O8 · 320.25 g/mol

What it is

A flavonoid from oriental raisin tree, traditionally used in Asia to mitigate intoxication and hangovers.

Also called

Hovenia dulcis flavonoidAmpelopsin

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Pre-Drinking SupportPost-Drinking RecoveryLiver Health

How it works

Upregulates ADH and ALDH activity; blocks alcohol's potentiation of GABA-A receptors, reducing intoxication and rebound anxiety.

Pathways

  • ADH/ALDH upregulation
  • GABA-A α1 modulation
  • Liver glutathione support

Effects

  • ↑Alcohol clearance rate increases
  • ↓Acetaldehyde accumulation decreases
  • ↓Hangover severity decreases

What the research supports

Animal evidence for ALD preventionmoderate
Reduces hangover symptoms in human trialslimited

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
300–600 mg before drinking; repeat before bed
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodBefore alcohol
Best formMost evidence is based on the capsule or softgel form.
Shop Dihydromyricetin (DHM) on Amazon ↗

As an Amazon Associate I earn from qualifying purchases. Look for USP, NSF or Informed Sport seals before you buy.

Side effects & interactions

Common side effects

  • Mild GI

Medication interactions

Prescription medications (general)minor

Always disclose Dihydromyricetin (DHM) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • NACGlutathione substrate for acetaldehyde clearance.
  • ElectrolytesCounter alcohol-induced diuresis.

Key studies

9 studies cited in total.

PubMed: Dihydromyricetin (DHM) — Reduces hangover symptoms in human trials ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Dihydromyricetin (DHM) and "Reduces hangover symptoms in human trials". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Dihydromyricetin (DHM) — Animal evidence for ALD prevention ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Dihydromyricetin (DHM) and "Animal evidence for ALD prevention". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Dihydromyricetin (DHM) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Dihydromyricetin (DHM) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

Discussion

Loading discussion…