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Compound

Dihydromyricetin (Extra)

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Dihydromyricetin (Extra). Hovenia dulcis flavanonol that accelerates ethanol clearance.

How it works. Upregulates alcohol and aldehyde dehydrogenases; positive allosteric modulator at GABA-A α1.

What the research supports. 1 graded claims. Strongest: Reduces hangover severity in small trials (limited).

How much to take. Typical dose: 300–600 mg before and after drinking.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Milk thistle (silymarin), NAC.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Dihydromyricetin (Extra). Anecdotes are not medical advice.

Dihydromyricetin (Extra). Hovenia dulcis flavanonol that accelerates ethanol clearance.

Molecular structureC15H12O8 · 320.25 g/mol

What it is

Hovenia dulcis flavanonol that accelerates ethanol clearance.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Liver Health

How it works

Upregulates alcohol and aldehyde dehydrogenases; positive allosteric modulator at GABA-A α1.

Pathways

  • Upregulates alcohol
  • aldehyde dehydrogenases
  • positive allosteric modulator at GABA-A α1

Effects

  • ↓hangover severity in small trials decreases

What the research supports

Reduces hangover severity in small trialslimited

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
300–600 mg before and after drinking
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith food
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • GI upset

Medication interactions

Prescription medications (general)minor

Always disclose Dihydromyricetin (Extra) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Dihydromyricetin (Extra) — Reduces hangover severity in small trials ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Dihydromyricetin (Extra) and "Reduces hangover severity in small trials". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Dihydromyricetin (Extra) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Dihydromyricetin (Extra) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Dihydromyricetin (Extra) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Dihydromyricetin (Extra) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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