TUDCA
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TUDCA. Bile acid with hepatoprotective effects and ER stress reduction.
How it works. Reduces ER stress and apoptosis; protects hepatocytes; mild bile salt.
What the research supports. 2 graded claims. Strongest: Improves LFTs in cholestasis (moderate).
How much to take. Typical dose: 250–500 mg/d (general); up to 1500 mg therapeutic.
Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.
Stacking. Pairs well with Milk thistle (silymarin), NAC, NAD+ precursor (NMN or NR).
Common forms. Available as TUDCA capsule.
Key studies. 9 studies cited. The strongest are listed with links to PubMed.
Community. Experiences from people who have tried TUDCA. Anecdotes are not medical advice.
TUDCA. Bile acid with hepatoprotective effects and ER stress reduction.
What it is
Bile acid with hepatoprotective effects and ER stress reduction.
Also called
Food sources
Goals
How it works
Reduces ER stress and apoptosis; protects hepatocytes; mild bile salt.
Pathways
- ER stress reduction
- Anti-apoptosis
Effects
- +Hepatocyte survival supports
- ↓ER stress decreases
What the research supports
Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.
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Side effects & interactions
Common side effects
- Diarrhea
Medication interactions
Reduce TUDCA absorption.
Check any supplement–medication combination with your pharmacist before starting.
Combines with
Pairs well
- Milk thistle (silymarin)Complementary hepatoprotective antioxidant pathways.
- NACRestores hepatic glutathione.
- NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
Common forms
- TUDCA capsule
Key studies
9 studies cited in total.
Opens current human and preclinical literature matching TUDCA and "Improves LFTs in cholestasis". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching TUDCA and "Used by AAS users for hepatoprotection". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching TUDCA and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
Discussion
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