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Herb

Siliphos (Silybin Phytosome)

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Siliphos (Silybin Phytosome). Silybin-phosphatidylcholine complex.

How it works. Increased bioavailability vs silymarin.

What the research supports. 1 graded claims. Strongest: Improves liver enzymes (moderate).

How much to take. Typical dose: 200 mg BID.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Milk thistle (silymarin), NAC.

Common forms. Available as Standardized extract capsule, Liquid tincture (alcohol or glycerin), Powdered whole herb, Traditional decoction or tea.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Siliphos (Silybin Phytosome). Anecdotes are not medical advice.

Siliphos (Silybin Phytosome). Silybin-phosphatidylcholine complex.

Key compound: silybinC25H22O10 · 482.4 g/mol

What it is

Silybin-phosphatidylcholine complex.

Food sources

Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice

Goals

Liver Health

How it works

Increased bioavailability vs silymarin.

Pathways

  • Increased bioavailability vs silymarin

Effects

  • +liver enzymes supports

What the research supports

Improves liver enzymesmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
200 mg BID
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the standardized extract capsule form.
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Side effects & interactions

Common side effects

  • GI upset

Medication interactions

Prescription medications (general)minor

Always disclose Siliphos (Silybin Phytosome) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

Common forms

  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Key studies

8 studies cited in total.

PubMed: Siliphos (Silybin Phytosome) — Improves liver enzymes ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Siliphos (Silybin Phytosome) and "Improves liver enzymes". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Siliphos (Silybin Phytosome) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Siliphos (Silybin Phytosome) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Siliphos (Silybin Phytosome) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Siliphos (Silybin Phytosome) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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