Supplement Scholar
Vitamin

Vitamin E

Buy on Amazon ↗

Affiliate link: we may earn a commission at no extra cost to you. Disclosures

Vitamin E. Primary lipid-phase antioxidant protecting membrane PUFAs.

How it works. Chain-breaking antioxidant in cell membranes; terminates lipid peroxidation cascades.

What the research supports. 2 graded claims. Strongest: Slows NAFLD progression (PIVENS trial) (moderate).

How much to take. Typical dose: 15 mg α-tocopherol.

Side effects and interactions. 1 medication interaction listed. Serious: Increased bleeding risk >400 IU + anticoagulants.

Stacking. Pairs well with Omega-3, CoQ10, Collagen peptides. Avoid combining with Pre-surgery.

Forms. 2 forms. Pick one to open its profile.

Key studies. 9 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Vitamin E. Anecdotes are not medical advice.

Vitamin E. Primary lipid-phase antioxidant protecting membrane PUFAs.

Key compound: alpha-tocopherolC29H50O2 · 430.7 g/mol

What it is

Primary lipid-phase antioxidant protecting membrane PUFAs.

Also called

Alpha-tocopherolMixed tocopherols

Food sources

Sunflower seedsAlmondsWheat germ oilAvocado

Goals

Cardiovascular HealthSkin, Hair & NailsHealthy Aging

How it works

Chain-breaking antioxidant in cell membranes; terminates lipid peroxidation cascades.

Pathways

  • Lipid peroxidation termination

Effects

  • ↓Lipid peroxidation decreases

What the research supports

Slows NAFLD progression (PIVENS trial)moderate
Improves nonalcoholic steatohepatitis histologymoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
15 mg α-tocopherol
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodYes (fat-soluble)
Best formMixed tocopherols
Upper limit1,000 mg
Shop Vitamin E on Amazon ↗

As an Amazon Associate I earn from qualifying purchases. Look for USP, NSF or Informed Sport seals before you buy.

Side effects & interactions

Serious

  • Increased bleeding risk >400 IU + anticoagulants

Medication interactions

Warfarin / antiplateletsmoderate

Additive bleeding risk.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Omega-3Anti-inflammatory cardiovascular synergy.
  • CoQ10Supports mitochondrial energetics in cardiac tissue.
  • Collagen peptidesProvides amino acid substrate for connective tissue synthesis.

Avoid combining

  • Pre-surgeryDiscontinue 1–2 weeks before surgery.

Key studies

9 studies cited in total.

PubMed: Vitamin E — Slows NAFLD progression ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Vitamin E and "Slows NAFLD progression". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Vitamin E — Improves nonalcoholic steatohepatitis histology ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Vitamin E and "Improves nonalcoholic steatohepatitis histology". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Vitamin E — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Vitamin E and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

Discussion

Loading discussion…