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Compound

Pomegranate Extract

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Pomegranate Extract. Punica granatum ellagitannins.

How it works. Ellagitannins reduce LDL oxidation.

What the research supports. 1 graded claims. Strongest: Improves carotid IMT (moderate).

How much to take. Typical dose: 500–1000 mg.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Omega-3, CoQ10.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Pomegranate Extract. Anecdotes are not medical advice.

Pomegranate Extract. Punica granatum ellagitannins.

Key compound: punicalaginC48H28O30 · 1084.7 g/mol

What it is

Punica granatum ellagitannins.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Cardiovascular HealthMen's Health

How it works

Ellagitannins reduce LDL oxidation.

Pathways

  • Ellagitannins reduce LDL oxidation

Effects

  • +carotid IMT supports

What the research supports

Improves carotid IMTmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
500–1000 mg
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • GI upset

Medication interactions

Prescription medications (general)minor

Always disclose Pomegranate Extract use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Omega-3Anti-inflammatory cardiovascular synergy.
  • CoQ10Supports mitochondrial energetics in cardiac tissue.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Pomegranate Extract — Improves carotid IMT ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Pomegranate Extract and "Improves carotid IMT". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Pomegranate Extract — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Pomegranate Extract and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Pomegranate Extract — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Pomegranate Extract and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

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