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Herb

Olive Leaf Extract

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Olive Leaf Extract. Mediterranean herb with antihypertensive and immune effects.

How it works. Oleuropein and hydroxytyrosol inhibit ACE and provide antioxidant effects.

What the research supports. 1 graded claims. Strongest: Reduces BP in pre-hypertensives (moderate).

How much to take. Typical dose: 500–1000 mg standardized.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Omega-3, CoQ10, Vitamin D3 + K2.

Common forms. Available as Standardized oleuropein.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Olive Leaf Extract. Anecdotes are not medical advice.

Olive Leaf Extract. Mediterranean herb with antihypertensive and immune effects.

Key compound: oleuropeinC25H32O13 · 540.5 g/mol

What it is

Mediterranean herb with antihypertensive and immune effects.

Also called

Oleuropein

Food sources

Olea europaea leaf

Goals

Cardiovascular HealthImmune FunctionBlood Sugar Management

How it works

Oleuropein and hydroxytyrosol inhibit ACE and provide antioxidant effects.

Pathways

  • ACE inhibition
  • Antioxidant

Effects

  • ↓Blood pressure decreases
  • ↓LDL oxidation decreases

What the research supports

Reduces BP in pre-hypertensivesmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
500–1000 mg standardized
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the standardized oleuropein form.
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Side effects & interactions

Common side effects

  • GI upset

Medication interactions

Antihypertensivesminor

Additive.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Omega-3Anti-inflammatory cardiovascular synergy.
  • CoQ10Supports mitochondrial energetics in cardiac tissue.
  • Vitamin D3 + K2Foundational immune modulation.

Common forms

  • Standardized oleuropein

Key studies

8 studies cited in total.

PubMed: Olive Leaf Extract — Reduces BP in pre-hypertensives ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Olive Leaf Extract and "Reduces BP in pre-hypertensives". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Olive Leaf Extract — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Olive Leaf Extract and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Olive Leaf Extract — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Olive Leaf Extract and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

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