L-Citrulline
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L-Citrulline. Arginine precursor with superior bioavailability for NO and pump-driven performance.
How it works. Bypasses hepatic first-pass metabolism, converted to arginine in kidneys, raises plasma arginine more than arginine itself.
What the research supports. 2 graded claims. Strongest: Improves resistance training reps to failure (moderate).
How much to take. Typical dose: 6–8 g citrulline malate or 3–6 g L-citrulline. 30–60 min pre-workout.
Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.
Stacking. Pairs well with Beta-alanine.
Common forms. Available as L-Citrulline, Citrulline malate (2:1).
Key studies. 9 studies cited. The strongest are listed with links to PubMed.
Community. Experiences from people who have tried L-Citrulline. Anecdotes are not medical advice.
L-Citrulline. Arginine precursor with superior bioavailability for NO and pump-driven performance.
What it is
Arginine precursor with superior bioavailability for NO and pump-driven performance.
Also called
Food sources
Goals
How it works
Bypasses hepatic first-pass metabolism, converted to arginine in kidneys, raises plasma arginine more than arginine itself.
Pathways
- NO synthesis
- Urea cycle
Effects
- ↑Plasma arginine increases
- ↑Nitric oxide increases
- ↓Perceived exertion decreases
What the research supports
Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.
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Side effects & interactions
Common side effects
- GI upset (rare)
Medication interactions
Additive hypotension.
Check any supplement–medication combination with your pharmacist before starting.
Common forms
- L-Citrulline
- Citrulline malate (2:1)
Key studies
9 studies cited in total.
Opens current human and preclinical literature matching L-Citrulline and "Improves resistance training reps to failure". Filter by RCT, meta-analysis, or year on the results page.
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Opens current human and preclinical literature matching L-Citrulline and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
Discussion
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