Supplement Scholar
Herb

Aged Garlic Extract (Kyolic)

Buy on Amazon ↗

Affiliate link: we may earn a commission at no extra cost to you. Disclosures

Aged Garlic Extract (Kyolic). Standardized aged garlic — modest BP and cholesterol benefits.

How it works. S-allyl cysteine modulates eNOS, ACE, and platelet aggregation.

What the research supports. 1 graded claims. Strongest: Lowers SBP ~7 mmHg in HTN (moderate).

How much to take. Typical dose: 600–1200 mg aged garlic extract.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Vitamin D3 + K2, Zinc.

Common forms. Available as Standardized extract capsule, Liquid tincture (alcohol or glycerin), Powdered whole herb, Traditional decoction or tea.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Aged Garlic Extract (Kyolic). Anecdotes are not medical advice.

Aged Garlic Extract (Kyolic). Standardized aged garlic — modest BP and cholesterol benefits.

Key compound: allicinC6H10OS2 · 162.3 g/mol

What it is

Standardized aged garlic — modest BP and cholesterol benefits.

Food sources

Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice

Goals

Blood PressureCholesterolCardiovascular Health (alias)Immune Function

How it works

S-allyl cysteine modulates eNOS, ACE, and platelet aggregation.

Pathways

  • S-allyl cysteine modulates eNOS, ACE
  • and platelet aggregation

Effects

  • ↓SBP ~7 mmHg in HTN decreases

What the research supports

Lowers SBP ~7 mmHg in HTNmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
600–1200 mg aged garlic extract
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodOptional
Best formMost evidence is based on the standardized extract capsule form.
Shop Aged Garlic Extract (Kyolic) on Amazon ↗

As an Amazon Associate I earn from qualifying purchases. Look for USP, NSF or Informed Sport seals before you buy.

Side effects & interactions

Common side effects

  • Garlic breath

Medication interactions

Anticoagulantsmoderate

Antiplatelet effect.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Vitamin D3 + K2Foundational immune modulation.
  • ZincRequired cofactor for innate and adaptive immune function.

Common forms

  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Key studies

8 studies cited in total.

PubMed: Aged Garlic Extract (Kyolic) — Lowers SBP ~7 mmHg in HTN ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "Lowers SBP ~7 mmHg in HTN". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Aged Garlic Extract (Kyolic) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Aged Garlic Extract (Kyolic) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Aged Garlic Extract (Kyolic) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

Loading discussion…