Supplement Scholar
Compound

Punicalagin

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Punicalagin. Major pomegranate ellagitannin.

How it works. Metabolized to urolithins by gut bacteria.

What the research supports. 1 graded claims. Strongest: Anti-inflammatory (moderate).

How much to take. Typical dose: 500 mg.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with NAD+ precursor (NMN or NR), Omega-3, CoQ10.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Punicalagin. Anecdotes are not medical advice.

Punicalagin. Major pomegranate ellagitannin.

Molecular structureC48H28O30 · 1084.7 g/mol

What it is

Major pomegranate ellagitannin.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Healthy AgingCardiovascular Health

How it works

Metabolized to urolithins by gut bacteria.

Pathways

  • Metabolized to urolithins by gut bacteria

Effects

  • +Anti-inflammatory supports

What the research supports

Anti-inflammatorymoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
500 mg
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • Well tolerated

Medication interactions

Prescription medications (general)minor

Always disclose Punicalagin use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
  • Omega-3Lowers inflammation and supports membrane integrity.
  • CoQ10Supports mitochondrial energetics in cardiac tissue.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Punicalagin — Anti-inflammatory ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Punicalagin and "Anti-inflammatory". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Punicalagin — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Punicalagin and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Punicalagin — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Punicalagin and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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