Supplement Scholar
Compound

Trans-Resveratrol

Buy on Amazon ↗

Affiliate link: we may earn a commission at no extra cost to you. Disclosures

Trans-Resveratrol. Active form of resveratrol.

How it works. Activates SIRT1; mimics caloric restriction.

What the research supports. 1 graded claims. Strongest: Improves insulin sensitivity (moderate).

How much to take. Typical dose: 150–500 mg.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with NAD+ precursor (NMN or NR), Omega-3, CoQ10.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Trans-Resveratrol. Anecdotes are not medical advice.

Trans-Resveratrol. Active form of resveratrol.

Molecular structureC14H12O3 · 228.24 g/mol

What it is

Active form of resveratrol.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Healthy AgingCardiovascular Health

How it works

Activates SIRT1; mimics caloric restriction.

Pathways

  • Activates SIRT1
  • mimics caloric restriction

Effects

  • +insulin sensitivity supports

What the research supports

Improves insulin sensitivitymoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
150–500 mg
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the capsule or softgel form.
Shop Trans-Resveratrol on Amazon ↗

As an Amazon Associate I earn from qualifying purchases. Look for USP, NSF or Informed Sport seals before you buy.

Side effects & interactions

Common side effects

  • GI upset

Medication interactions

Prescription medications (general)minor

Always disclose Trans-Resveratrol use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.
  • Omega-3Lowers inflammation and supports membrane integrity.
  • CoQ10Supports mitochondrial energetics in cardiac tissue.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

Trans-resveratrol meta-analysis ↗
Meta-analysis · Am J Clin Nutr · 2014

Improved glucose control in T2DM.

PubMed: Trans-Resveratrol — Improves insulin sensitivity ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Trans-Resveratrol and "Improves insulin sensitivity". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Trans-Resveratrol — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Trans-Resveratrol and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

Discussion

Loading discussion…