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Green Tea (EGCG)

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Green Tea (EGCG). Polyphenol-rich tea; EGCG modestly boosts metabolism and supports cardiovascular health.

How it works. EGCG inhibits COMT (preserves catecholamines) and modulates DNA methylation.

What the research supports. 2 graded claims. Strongest: Modest weight loss (~1–2 kg) over 12 weeks (moderate).

How much to take. Typical dose: 300–500 mg EGCG with food.

Side effects and interactions. 2 medication interactions listed. Serious: Hepatotoxicity at >800 mg EGCG/d fasted.

Stacking. Pairs well with Omega-3, CoQ10, NAD+ precursor (NMN or NR). Avoid combining with Fasted high-dose EGCG.

Common forms. Available as Brewed tea, Matcha, EGCG extract.

Key studies. 9 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Green Tea (EGCG). Anecdotes are not medical advice.

Green Tea (EGCG). Polyphenol-rich tea; EGCG modestly boosts metabolism and supports cardiovascular health.

Key compound: epigallocatechin gallateC22H18O11 · 458.4 g/mol

What it is

Polyphenol-rich tea; EGCG modestly boosts metabolism and supports cardiovascular health.

Also called

Camellia sinensisEGCG

Food sources

Camellia sinensis

Goals

Fat LossCardiovascular HealthHealthy Aging

How it works

EGCG inhibits COMT (preserves catecholamines) and modulates DNA methylation.

Pathways

  • COMT inhibition
  • Thermogenesis

Effects

  • ↑Energy expenditure (~3–4%) increases
  • +Antioxidant defense supports

What the research supports

Modest weight loss (~1–2 kg) over 12 weeksmoderate
Reduces LDL cholesterolmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
300–500 mg EGCG with food
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the brewed tea form.
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Side effects & interactions

Common side effects

  • Caffeine effects

Serious

  • Hepatotoxicity at >800 mg EGCG/d fasted

Medication interactions

Nadololmoderate

Significantly reduces absorption.

Anticoagulantsminor

Vitamin K content.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Omega-3Anti-inflammatory cardiovascular synergy.
  • CoQ10Supports mitochondrial energetics in cardiac tissue.
  • NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.

Avoid combining

  • Fasted high-dose EGCGHepatotoxicity risk.

Common forms

  • Brewed tea
  • Matcha
  • EGCG extract

Key studies

9 studies cited in total.

Green tea catechins and cardiometabolic health ↗
Meta-analysis · Cochrane Database · 2013

Small but significant reductions in LDL and blood pressure.

PubMed: Green Tea (EGCG) — Modest weight lossover 12 weeks ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Green Tea (EGCG) and "Modest weight lossover 12 weeks". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Green Tea (EGCG) — Reduces LDL cholesterol ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Green Tea (EGCG) and "Reduces LDL cholesterol". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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