Supplement Scholar
Fatty Acid

Perilla Oil

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Perilla Oil. High ALA from Perilla frutescens.

How it works. High alpha-linolenic acid.

What the research supports. 1 graded claims. Strongest: ALA source for vegans (moderate).

How much to take. Typical dose: 2 g ALA.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Omega-3, CoQ10.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Perilla Oil. Anecdotes are not medical advice.

Perilla Oil. High ALA from Perilla frutescens.

Key compound: alpha-linolenic acidC18H30O2 · 278.4 g/mol

What it is

High ALA from Perilla frutescens.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Cardiovascular Health

How it works

High alpha-linolenic acid.

Pathways

  • High alpha-linolenic acid

Effects

  • +ALA source for vegans supports

What the research supports

ALA source for vegansmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
2 g ALA
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • Well tolerated

Medication interactions

Prescription medications (general)minor

Always disclose Perilla Oil use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Omega-3Anti-inflammatory cardiovascular synergy.
  • CoQ10Supports mitochondrial energetics in cardiac tissue.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Perilla Oil — ALA source for vegans ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Perilla Oil and "ALA source for vegans". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Perilla Oil — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Perilla Oil and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Perilla Oil — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Perilla Oil and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

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