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Bergamot Extract

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Bergamot Extract. Citrus bergamia for cardiometabolic support.

How it works. Brutieridine and melitidine inhibit HMG-CoA reductase.

What the research supports. 1 graded claims. Strongest: Lowers LDL and triglycerides (moderate).

How much to take. Typical dose: 500–1000 mg BPF.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Omega-3, CoQ10.

Common forms. Available as Standardized extract capsule, Liquid tincture (alcohol or glycerin), Powdered whole herb, Traditional decoction or tea.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Bergamot Extract. Anecdotes are not medical advice.

Bergamot Extract. Citrus bergamia for cardiometabolic support.

Key compound: brutieridinC34H42O19 · 754.7 g/mol

What it is

Citrus bergamia for cardiometabolic support.

Food sources

Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice

Goals

Cardiovascular Health

How it works

Brutieridine and melitidine inhibit HMG-CoA reductase.

Pathways

  • Brutieridine
  • melitidine inhibit HMG-CoA reductase

Effects

  • ↓LDL and triglycerides decreases

What the research supports

Lowers LDL and triglyceridesmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
500–1000 mg BPF
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the standardized extract capsule form.
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Side effects & interactions

Common side effects

  • GI upset

Medication interactions

Prescription medications (general)minor

Always disclose Bergamot Extract use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Omega-3Anti-inflammatory cardiovascular synergy.
  • CoQ10Supports mitochondrial energetics in cardiac tissue.

Common forms

  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Key studies

8 studies cited in total.

PubMed: Bergamot Extract — Lowers LDL and triglycerides ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Bergamot Extract and "Lowers LDL and triglycerides". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Bergamot Extract — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Bergamot Extract and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Bergamot Extract — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Bergamot Extract and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

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