Niacin Extended Release
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Niacin Extended Release. Slow-release nicotinic acid for cholesterol.
How it works. Inhibits hepatic VLDL synthesis; raises HDL.
What the research supports. 1 graded claims. Strongest: Raises HDL 15–35% (moderate).
How much to take. Typical dose: 500–2000 mg at bedtime.
Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.
Stacking. Pairs well with Omega-3, CoQ10.
Common forms. Available as Capsule or softgel, Sublingual tablet or liquid, Methylated active form for sensitive individuals, Multivitamin matrix.
Key studies. 8 studies cited. The strongest are listed with links to PubMed.
Community. Experiences from people who have tried Niacin Extended Release. Anecdotes are not medical advice.
Niacin Extended Release. Slow-release nicotinic acid for cholesterol.
What it is
Slow-release nicotinic acid for cholesterol.
Food sources
Goals
How it works
Inhibits hepatic VLDL synthesis; raises HDL.
Pathways
- Inhibits hepatic VLDL synthesis
- raises HDL
Effects
- ↑HDL 15–35% increases
What the research supports
Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.
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Side effects & interactions
Common side effects
- Flushing
- Hepatotoxicity
- Glucose intolerance
Medication interactions
Always disclose Niacin Extended Release use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
Check any supplement–medication combination with your pharmacist before starting.
Combines with
Pairs well
- Omega-3Anti-inflammatory cardiovascular synergy.
- CoQ10Supports mitochondrial energetics in cardiac tissue.
Common forms
- Capsule or softgel
- Sublingual tablet or liquid
- Methylated active form for sensitive individuals
- Multivitamin matrix
Key studies
8 studies cited in total.
Opens current human and preclinical literature matching Niacin Extended Release and "Raises HDL 15–35%". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Niacin Extended Release and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Niacin Extended Release and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.
Discussion
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