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Compound

Type III Collagen

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Type III Collagen. Skin and vascular collagen.

How it works. Component of skin, blood vessels, organs.

What the research supports. 1 graded claims. Strongest: Skin support (moderate).

How much to take. Typical dose: 2.5–10 g.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Collagen peptides, Vitamin C, Omega-3.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Type III Collagen. Anecdotes are not medical advice.

Type III Collagen. Skin and vascular collagen.

Key compound: prolylhydroxyprolineC10H16N2O4 · 228.24 g/mol

What it is

Skin and vascular collagen.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Skin, Hair & NailsCardiovascular Health

How it works

Component of skin, blood vessels, organs.

Pathways

  • Component of skin, blood vessels, organs

Effects

  • +Skin support supports

What the research supports

Skin supportmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
2.5–10 g
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • Well tolerated

Medication interactions

Prescription medications (general)minor

Always disclose Type III Collagen use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Collagen peptidesProvides amino acid substrate for connective tissue synthesis.
  • Vitamin CRequired cofactor for collagen hydroxylation.
  • Omega-3Anti-inflammatory cardiovascular synergy.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Type III Collagen — Skin support ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Type III Collagen and "Skin support". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Type III Collagen — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Type III Collagen and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Type III Collagen — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Type III Collagen and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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