Supplement Scholar
Fatty Acid

Krill Oil

Buy on Amazon ↗

Affiliate link: we may earn a commission at no extra cost to you. Disclosures

Krill Oil. Phospholipid-bound omega-3 with astaxanthin; better bioavailability than fish oil per gram.

How it works. EPA/DHA bound to phospholipids (vs triglycerides in fish oil) for better incorporation.

What the research supports. 1 graded claims. Strongest: Reduces TG and inflammatory markers (moderate).

How much to take. Typical dose: 1–3 g/d (300–600 mg EPA+DHA).

Side effects and interactions. 1 medication interaction listed. Serious: Shellfish allergy.

Stacking. Pairs well with Omega-3, CoQ10, NAD+ precursor (NMN or NR). Avoid combining with Shellfish allergy.

Common forms. Available as Krill oil.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Krill Oil. Anecdotes are not medical advice.

Krill Oil. Phospholipid-bound omega-3 with astaxanthin; better bioavailability than fish oil per gram.

Key compound: eicosapentaenoic acidC20H30O2 · 302.5 g/mol

What it is

Phospholipid-bound omega-3 with astaxanthin; better bioavailability than fish oil per gram.

Food sources

Antarctic krill

Goals

Cardiovascular HealthJoint & Connective TissueHealthy Aging

How it works

EPA/DHA bound to phospholipids (vs triglycerides in fish oil) for better incorporation.

Pathways

  • EPA/DHA incorporation

Effects

  • ↓Triglycerides decreases

What the research supports

Reduces TG and inflammatory markersmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
1–3 g/d (300–600 mg EPA+DHA)
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the krill oil form.
Shop Krill Oil on Amazon ↗

As an Amazon Associate I earn from qualifying purchases. Look for USP, NSF or Informed Sport seals before you buy.

Side effects & interactions

Common side effects

  • Fish burp (less than fish oil)

Serious

  • Shellfish allergy

Medication interactions

Anticoagulantsmoderate

Mild antiplatelet.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Omega-3Anti-inflammatory cardiovascular synergy.
  • CoQ10Supports mitochondrial energetics in cardiac tissue.
  • NAD+ precursor (NMN or NR)Complementary mitochondrial and sirtuin support.

Avoid combining

  • Shellfish allergyCrustacean source.

Common forms

  • Krill oil

Key studies

8 studies cited in total.

PubMed: Krill Oil — Reduces TG and inflammatory markers ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Krill Oil and "Reduces TG and inflammatory markers". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Krill Oil — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Krill Oil and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Krill Oil — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Krill Oil and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

Loading discussion…