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Fatty Acid

Black Seed Oil (Nigella sativa)

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Black Seed Oil (Nigella sativa). Thymoquinone for immune and metabolic health.

How it works. Thymoquinone is antioxidant and anti-inflammatory.

What the research supports. 1 graded claims. Strongest: Improves glucose and lipids (moderate).

How much to take. Typical dose: 1–3 g.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Vitamin D3 + K2, Zinc, Omega-3.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Black Seed Oil (Nigella sativa). Anecdotes are not medical advice.

Black Seed Oil (Nigella sativa). Thymoquinone for immune and metabolic health.

Key compound: thymoquinoneC10H12O2 · 164.20 g/mol

What it is

Thymoquinone for immune and metabolic health.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Immune FunctionCardiovascular Health

How it works

Thymoquinone is antioxidant and anti-inflammatory.

Pathways

  • Thymoquinone is antioxidant
  • anti-inflammatory

Effects

  • +glucose and lipids supports

What the research supports

Improves glucose and lipidsmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
1–3 g
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • GI upset

Medication interactions

Prescription medications (general)minor

Always disclose Black Seed Oil (Nigella sativa) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Vitamin D3 + K2Foundational immune modulation.
  • ZincRequired cofactor for innate and adaptive immune function.
  • Omega-3Anti-inflammatory cardiovascular synergy.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

Nigella sativa meta-analysis ↗
Meta-analysis · Pharmacol Res · 2016

Improved glycemic and lipid profiles.

PubMed: Black Seed Oil (Nigella sativa) — Improves glucose and lipids ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Black Seed Oil (Nigella sativa) and "Improves glucose and lipids". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Black Seed Oil (Nigella sativa) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Black Seed Oil (Nigella sativa) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

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