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Bergamot Extract

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Bergamot Extract. Standardized citrus polyphenol fraction shown to lower LDL and triglycerides.

How it works. Polyphenols inhibit HMG-CoA reductase and increase LDL receptor expression.

What the research supports. 1 graded claims. Strongest: Reduces LDL & TG, raises HDL (moderate).

How much to take. Typical dose: 500–1500 mg BPF.

Side effects and interactions. 1 medication interaction listed. Serious: Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing.

Stacking. Pairs well with Omega-3, CoQ10.

Common forms. Available as Bergamot Polyphenolic Fraction (BPF).

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Bergamot Extract. Anecdotes are not medical advice.

Bergamot Extract. Standardized citrus polyphenol fraction shown to lower LDL and triglycerides.

Key compound: brutieridinC34H42O19 · 754.7 g/mol

What it is

Standardized citrus polyphenol fraction shown to lower LDL and triglycerides.

Also called

Citrus bergamia

Food sources

Citrus bergamia

Goals

Cardiovascular Health

How it works

Polyphenols inhibit HMG-CoA reductase and increase LDL receptor expression.

Pathways

  • HMG-CoA inhibition
  • LDLR upregulation

Effects

  • ↓LDL cholesterol decreases
  • ↓Triglycerides decreases

What the research supports

Reduces LDL & TG, raises HDLmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
500–1500 mg BPF
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the bergamot polyphenolic fraction (bpf) form.
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Side effects & interactions

Common side effects

  • Bergamot Extract is generally well-tolerated at evidence-based doses
  • Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
  • Headache or transient fatigue reported by a small fraction of users

Serious

  • Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing

Medication interactions

Statinsminor

Additive — may allow lower dose.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Omega-3Anti-inflammatory cardiovascular synergy.
  • CoQ10Supports mitochondrial energetics in cardiac tissue.

Common forms

  • Bergamot Polyphenolic Fraction (BPF)

Key studies

8 studies cited in total.

PubMed: Bergamot Extract — Reduces LDL & TG, raises HDL ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Bergamot Extract and "Reduces LDL & TG, raises HDL". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Bergamot Extract — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Bergamot Extract and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Bergamot Extract — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Bergamot Extract and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

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