Omega-3 (EPA/DHA)
Affiliate link: we may earn a commission at no extra cost to you. Disclosures
Omega-3 (EPA/DHA). Marine long-chain omega-3s — the most-studied anti-inflammatory and cardiovascular nutrient.
How it works. EPA/DHA replace arachidonic acid in cell membranes, shifting eicosanoid production from pro-inflammatory (PGE2) to resolution mediators (resolvins, protectins).
What the research supports. 4 graded claims. Strongest: Reduces triglycerides (strong).
How much to take. Typical dose: 2–3 g combined EPA+DHA. With largest fatty meal.
Side effects and interactions. 2 medication interactions listed. Serious: Atrial fibrillation risk at 4 g/day in some trials.
Stacking. Pairs well with Vitamin E, Vitamin D3. Avoid combining with High-dose vitamin E + other antioxidants.
Forms. 2 forms. Pick one to open its profile.
Key studies. 11 studies cited. The strongest are listed with links to PubMed.
Community. Experiences from people who have tried Omega-3 (EPA/DHA). Anecdotes are not medical advice.
Omega-3 (EPA/DHA). Marine long-chain omega-3s — the most-studied anti-inflammatory and cardiovascular nutrient.
What it is
Long-chain polyunsaturated fatty acids (EPA and DHA) found in fatty fish and algae. Incorporated into cell membranes and serve as precursors to anti-inflammatory eicosanoids.
Also called
Food sources
Goals
How it works
EPA/DHA replace arachidonic acid in cell membranes, shifting eicosanoid production from pro-inflammatory (PGE2) to resolution mediators (resolvins, protectins).
Pathways
- Eicosanoid production (COX/LOX)
- Specialized pro-resolving mediators (SPMs)
- Membrane fluidity
Effects
- ↓Triglycerides (~20–30%) decreases
- ↓Systemic inflammation (hs-CRP) decreases
- +Membrane health & cognition supports
- ↓Resting heart rate decreases
What the research supports
Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.
As an Amazon Associate I earn from qualifying purchases. Look for USP, NSF or Informed Sport seals before you buy.
Side effects & interactions
Common side effects
- Fishy burps
- Mild GI upset
Serious
- Atrial fibrillation risk at 4 g/day in some trials
Medication interactions
May increase bleeding risk at high doses.
Additive BP lowering.
Check any supplement–medication combination with your pharmacist before starting.
Combines with
Pairs well
- Vitamin EProtects PUFAs from peroxidation.
- Vitamin D3Synergistic for cardiovascular and immune health.
Avoid combining
- High-dose vitamin E + other antioxidantsMay blunt some adaptive responses to training.
Key studies
11 studies cited in total.
Opens current human and preclinical literature matching Omega-3 (EPA/DHA) and "Reduces triglycerides". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Omega-3 (EPA/DHA) and "Reduces major cardiovascular events at high-dose prescription EPA". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Omega-3 (EPA/DHA) and "Reduces depression severity". Filter by RCT, meta-analysis, or year on the results page.
Discussion
Loading discussion…