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Compound

TMG (Betaine Anhydrous)

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TMG (Betaine Anhydrous). Methyl donor for homocysteine reduction.

How it works. Methylates homocysteine to methionine.

What the research supports. 1 graded claims. Strongest: Lowers homocysteine (moderate).

How much to take. Typical dose: 3–6 g.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Omega-3, CoQ10.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried TMG (Betaine Anhydrous). Anecdotes are not medical advice.

TMG (Betaine Anhydrous). Methyl donor for homocysteine reduction.

Molecular structureC5H11NO2 · 117.15 g/mol

What it is

Methyl donor for homocysteine reduction.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Cardiovascular Health

How it works

Methylates homocysteine to methionine.

Pathways

  • Methylates homocysteine to methionine

Effects

  • ↓homocysteine decreases

What the research supports

Lowers homocysteinemoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
3–6 g
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • GI upset

Medication interactions

Prescription medications (general)minor

Always disclose TMG (Betaine Anhydrous) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Omega-3Anti-inflammatory cardiovascular synergy.
  • CoQ10Supports mitochondrial energetics in cardiac tissue.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: TMG (Betaine Anhydrous) — Lowers homocysteine ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching TMG (Betaine Anhydrous) and "Lowers homocysteine". Filter by RCT, meta-analysis, or year on the results page.

PubMed: TMG (Betaine Anhydrous) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching TMG (Betaine Anhydrous) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: TMG (Betaine Anhydrous) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching TMG (Betaine Anhydrous) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

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