Supplement Scholar
Compound

2S-Hesperidin (Cardiose)

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2S-Hesperidin (Cardiose). Bioactive isomer of hesperidin.

How it works. Higher bioavailability; vasoprotective.

What the research supports. 1 graded claims. Strongest: Improves endothelial function (moderate).

How much to take. Typical dose: 500 mg.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Omega-3, CoQ10.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried 2S-Hesperidin (Cardiose). Anecdotes are not medical advice.

2S-Hesperidin (Cardiose). Bioactive isomer of hesperidin.

Molecular structureC28H34O15 · 610.6 g/mol

What it is

Bioactive isomer of hesperidin.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Cardiovascular HealthAthletic Performance

How it works

Higher bioavailability; vasoprotective.

Pathways

  • Higher bioavailability
  • vasoprotective

Effects

  • +endothelial function supports

What the research supports

Improves endothelial functionmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
500 mg
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • Well tolerated

Medication interactions

Prescription medications (general)minor

Always disclose 2S-Hesperidin (Cardiose) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Omega-3Anti-inflammatory cardiovascular synergy.
  • CoQ10Supports mitochondrial energetics in cardiac tissue.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: 2S-Hesperidin (Cardiose) — Improves endothelial function ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching 2S-Hesperidin (Cardiose) and "Improves endothelial function". Filter by RCT, meta-analysis, or year on the results page.

PubMed: 2S-Hesperidin (Cardiose) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching 2S-Hesperidin (Cardiose) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: 2S-Hesperidin (Cardiose) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching 2S-Hesperidin (Cardiose) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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