Supplement Scholar
Herb

Centella Triterpene Fraction

Buy on Amazon ↗

Affiliate link: we may earn a commission at no extra cost to you. Disclosures

Centella Triterpene Fraction. Standardized madecassoside/asiaticoside for skin and venous health.

How it works. Triterpenes stimulate type I collagen.

What the research supports. 1 graded claims. Strongest: Improves scar healing (moderate).

How much to take. Typical dose: 60–120 mg standardized.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Collagen peptides, Vitamin C, Omega-3.

Common forms. Available as Standardized extract capsule, Liquid tincture (alcohol or glycerin), Powdered whole herb, Traditional decoction or tea.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Centella Triterpene Fraction. Anecdotes are not medical advice.

Centella Triterpene Fraction. Standardized madecassoside/asiaticoside for skin and venous health.

Key compound: asiatic acidC30H48O5 · 488.7 g/mol

What it is

Standardized madecassoside/asiaticoside for skin and venous health.

Food sources

Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice

Goals

Skin, Hair & NailsCardiovascular Health

How it works

Triterpenes stimulate type I collagen.

Pathways

  • Triterpenes stimulate type I collagen

Effects

  • +scar healing supports

What the research supports

Improves scar healingmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
60–120 mg standardized
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the standardized extract capsule form.
Shop Centella Triterpene Fraction on Amazon ↗

As an Amazon Associate I earn from qualifying purchases. Look for USP, NSF or Informed Sport seals before you buy.

Side effects & interactions

Common side effects

  • Skin irritation

Medication interactions

Prescription medications (general)minor

Always disclose Centella Triterpene Fraction use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Collagen peptidesProvides amino acid substrate for connective tissue synthesis.
  • Vitamin CRequired cofactor for collagen hydroxylation.
  • Omega-3Anti-inflammatory cardiovascular synergy.

Common forms

  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Key studies

8 studies cited in total.

PubMed: Centella Triterpene Fraction — Improves scar healing ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Centella Triterpene Fraction and "Improves scar healing". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Centella Triterpene Fraction — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Centella Triterpene Fraction and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Centella Triterpene Fraction — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Centella Triterpene Fraction and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

Loading discussion…